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TranscriptomicsData expression in alveolar macrophages induced by lipopolysaccharide in humans
Rationale: Lipopolysaccharide (LPS) is ubiquitous in the environment. Inhalation of LPS has been implicated in the pathogenesis and/or severity of several lung diseases, including pneumonia, chronic obstructive pulmonary disease and asthma. Alveolar macrophages are the main resident leukocytes expos...
ORGANISM(S): Homo sapiens 
2012-09-15 | E-GEOD-40885 | biostudies-arrayexpress
TranscriptomicsEarly and dynamic changes in gene expression in septic shock patients: a genome wide approach
Background: As early and appropriate care of severe septic patients is associated with better outcome, understanding of very first events in the disease process is needed. Pan-genomic analyses offer an interesting opportunity to study global genomic response within the very first hours after sepsis....
ORGANISM(S): Homo sapiens 
2014-11-05 | E-GEOD-57065 | biostudies-arrayexpress
TranscriptomicsIDENTIFICATION OF BIOMARKERS OF RESPONSE TO IFNG DURING ENDOTOXIN TOLERANCE: APPLICATION TO SEPTIC SHOCK
The rapid development in septic patients of features of marked immunosuppression associated with increased risk of nosocomial infections and mortality represents the rational for the initiation of immune targeted treatments in sepsis. However, as there is no clinical sign of immune dysfunctions, the...
ORGANISM(S): Homo sapiens 
2013-07-31 | E-GEOD-46914 | biostudies-arrayexpress
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