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TranscriptomicsMiR-511 dependently expressed genes in monoblastic cell line THP1
To experimentally investigate the function of hsa-miR-511-5p in AML monoblasts, we employed miRNA mimic mediated up-regulation of miR-511 in THP1 cells and subsequently analyzed a comprehensive gene expression profile. 4 samples of two independent miRNA mimic experiments were analyzed. THP1 monoblas...
ORGANISM(S): Homo sapiens 
2016-01-16 | E-GEOD-70490 | biostudies-arrayexpress
TranscriptomicsRNAi-mediated silencing of MLL-AF9 reveals leukemia-associated downstream targets and processes
The translocation t(9;11)(p22;q23) leading to the leukemogenic fusion gene MLL-AF9 is a frequent translocation in infant acute myeloid leukemia (AML). This study aimed to identify genes and molecular processes downstream of MLL-AF9 (alias MLL-MLLT3) which could assist to develop new targeted therapi...
ORGANISM(S): Homo sapiens 
2014-02-13 | E-GEOD-36592 | biostudies-arrayexpress
ProteomicsIon Mobility-Tandem Mass Spectrometry of Mucin-type O-Glycans
The dense O-glycosylation of mucins plays an important role in the defensive properties of the mucus hydrogel. Aberrant glycosylation is often correlated with inflammation and pathology such as COPD, cancer, and Crohn’s disease. The inherent complexity of glycans and the diversity in the O-core stru...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2024-03-19 | PXD050530 | Pride
O-glycans  ion mobility  mass spectrometry  isomeric separation  dda  proteome 
TranscriptomicsMiRNome and transcriptome aided pathway analysis in human regulatory T cells
Owing to their manifold immune regulatory functions, regulatory T cells (Treg) have received tremendous interests as targets for therapeutic intervention of diverse immunological pathologies or cancer. Directed manipulation of Treg will only be achievable with extensive knowledge about the intrinsic...
ORGANISM(S): Homo sapiens 
2014-05-23 | E-GEOD-54953 | biostudies-arrayexpress
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