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TranscriptomicsSLAMF1/CD150 regulates chemotaxis, autophagy and therapy responses in chronic lymphocytic leukemia patients
This work shows that signaling-lymphocytic-activation-molecule-1 (SLAMF1), a co-stimulatory molecule and a microbial sensor, is expressed by normal CD19+/CD5+ B-lymphocytes. Its expression is lost in a subset of patients with chronic lymphocytic leukemia (CLL) characterized by an aggressive form of ...
ORGANISM(S): Homo sapiens 
2015-05-23 | E-GEOD-69165 | biostudies-arrayexpress
TranscriptomicsThe enzymatic activities of CD38 enhance CLL growth and trafficking: implications for therapeutic targeting
The ecto-enzyme CD38 is a marker of unfavorable prognosis for chronic lymphocytic leukemia (CLL) patients and an indicator of activation and proliferation of leukemic cells. Here we show that CD38 is enzymatically active in primary CLL cells and that its forced expression increases disease aggressiv...
ORGANISM(S): Homo sapiens 
2014-04-01 | E-GEOD-56369 | biostudies-arrayexpress
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