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GenomicsGenome-wide map of H3K4me3 in 12 day post-partum mouse spermatocytes
Here we characterize the genome-wide chromatin modification by PRDM9, a histone H3 lysine 4 methyltransferase. In order to detect PRDM9 binding sites we created coisogenic strains of mice differing only in the zinc finger array of PRDM9. One strain is C57BL/6J, which carries the Prdm9Dom2 allele, th...
ORGANISM(S): Mus musculus 
2014-02-24 | E-GEOD-52628 | biostudies-arrayexpress
GenomicsGenome-wide map of H3K4me3 and PRDM9-binding in 12 day post-partum mouse spermatocytes
PRDM9, a histone methyltransferase, initiates meiotic recombination by binding DNA at recombination hotspots and directing the position of DNA double-strand breaks (DSB). The DSB repair mechanism suggests that hotspots should eventually self-destruct, yet genome-wide recombination levels remain cons...
ORGANISM(S): Mus musculus 
2015-01-13 | E-GEOD-60906 | biostudies-arrayexpress
GenomicsGenome-wide map of H3K4me3 in HEK293 cells after PRDM9 expression
PRDM9 is a histone methyltransferase expressed in meiotic germ cells that determines the location of genetic recombination hotspots through binding of its allele-specific DNA binding domain. Here we characterize the genome-wide chromatin modification for two human PRDM9 alleles (A and C) in human ce...
ORGANISM(S): Homo sapiens 
2015-09-21 | E-GEOD-67673 | biostudies-arrayexpress
TranscriptomicsMRLxSM eQTL in Liver by RMA on Ensembl transcripts
A QTL analysis between inbred mouse strains MRL/MpJ and SM/J was performed to identify genetic loci influencing high-density lipoprotein (HDL) cholesterol and triglycerides (TG) at eight weeks of age in F2 mice fed a chow diet. In order to narrow down lists of candidate genes, expression levels from...
ORGANISM(S): Mus musculus 
2011-11-28 | E-GEOD-25322 | biostudies-arrayexpress
GenomicsEGAS00001000462-sc-20170511 - samples
The offspring of first cousin marriages have ~6% of their genome autozygous, i.e. homozygous identical by descent, or even more if there was further consanguinity in their ancestry. In the UK there are large populations with very high first cousin marriage rates of 20-50%. Sequencing the exomes of...
EGAD00001003329 | EGA
GenomicsEGAS00001000462-sc-20141120 - samples
The offspring of first cousin marriages have ~6% of their genome autozygous, i.e. homozygous identical by descent, or even more if there was further consanguinity in their ancestry. In the UK there are large populations with very high first cousin marriage rates of 20-50%. Sequencing the exomes of...
EGAD00001001079 | EGA
GenomicsAutozygosity pilot Born in Bradford
The offspring of first cousin marriages have ~6% of their genome autozygous, i.e. homozygous identical by descent, or even more if there was further consanguinity in their ancestry. In the UK there are large populations with very high first cousin marriage rates of 20-50%. Sequencing the exomes of...
EGAS00001000462 | EGA
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