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MetabolomicsSerum Metabolomics in the Rat Model of Recurrent Pelvic Pain

This study aimed to investigate systemic metabolic alterations underlying pain-depression comorbidity in the Recurrent Pelvic Pain (RPP) rat model using untargeted serum metabolomics (UPLC-Q-Orbitrap-MS). Comparative analysis revealed distinct metabolic profiles, identifying 234 differential meta...

2026-02-11 | MTBLS13869 | MetaboLights
MetabolomicsThe effect and mechanism of gut flora metabolite deaminotyrosine on chronic inflammatory pain

This study focuses on deaminotyrosine DAT, a metabolite of gut flora, and systematically investigates its effect on chronic inflammatory pain as well as the underlying mechanism. The research takes high-fat diet HFD as a key entry point for the background, as HFD often leads to an imbalance in th...

2026-08-10 | MTBLS13212 | MetaboLights
MetabolomicsThe effect and mechanism of gut flora metabolite deaminotyrosine on chronic inflammatory pain

This study focuses on deaminotyrosine DAT, a metabolite of gut flora, and systematically investigates its effect on chronic inflammatory pain as well as the underlying mechanism. The research takes high-fat diet HFD as a key entry point for the background, as HFD often leads to an imbalance in th...

2026-08-10 | MTBLS13221 | MetaboLights
TranscriptomicsRNA-seq of rat dorsal root ganglia after ligation to investigate central nervous system transcriptomics in chronic pain using agnostic splice site discovery methods
The study pursued dual goals: To advance mRNA-seq bioinformatics towards unbiased transcriptome capture and to demonstrate its potential for discovery in neuroscience by applying the approach to an in vivo model of neurological disease. We found that 12.4% of known genes were induced and 7% were sup...
ORGANISM(S): Rattus norvegicus 
2010-05-01 | E-GEOD-20895 | biostudies-arrayexpress
Transcriptomicsnuclear calcium regulated genes in spinal neurons during inflammatory pain
Identification of a pain-associated, nuclear calcium-regulated gene program in spinal excitatory neurons during inflammatory pain, using a nucleus-specific calcium signal perturbation strategy in vivo complemented by gene profiling
ORGANISM(S): Mus musculus 
2013-12-13 | E-MTAB-1416 | biostudies-arrayexpress
TranscriptomicsMicroarray analyses of mouse dorsal root ganglia tissue for six different pain models
Six different mouse pain models were studied: (1) tumour-injection model for bone cancer pain; (2) partial sciatic nerve ligation (PSL) for neuropathic pain; (3) mechanical joint loading for osteoarthritis pain; (4) oxaliplatin-induced painful neuropathy for chemotherapy-induced pain; (5) hyperalges...
ORGANISM(S): Mus musculus 
2018-06-11 | E-MTAB-6864 | biostudies-arrayexpress
ProteomicsIntegrative multiomic analyses of dorsal root ganglia in diabetic neuropathic pain using proteomics, phosphoproteomics, and metabolomics
Diabetic peripheral neuropathy (DPN) is characterized by spontaneous pain in the extremities. Incidence of DPN continues to rise with the global diabetes epidemic. However, there remains a lack of safe, effective analgesics to control this chronic painful condition. Dorsal root ganglia (DRG) contain...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-01-09 | MSV000091027 | MassIVE
ProteomicsThe proteome of acute muscle pain: Observations from acute hypertonic saline induced pain in humans
Despite widespread use of experimental acute pain models to mimic chronic pathologies, little exploration has been undertaken on the acute pain proteome in humans. We re-solved to explore molecular alterations evoked by acute bouts of hypertonic saline (HS) induced muscle pain and map the spread of...
ORGANISM(S): Homo sapiens (Human) 
2026-01-05 | PXD070131 | Pride
Human Untargeted proteomics Acute pain Nociception 
MetabolomicsExploring Salivary Metabolites as Biomarkers in Chronic Craniofacial and Orofacial Pain: A Metabolomic Analysis.
Chronic facial pain (CFP) includes a range of conditions such as musculoskeletal, neurovascular, and neuropathic disorders affecting the facial and jaw regions, often causing significant distress to patients. This study aims to investigate the metabolomic profile of patients with CFP, focusing on sa...
2025-07-16 | MTBLS12704 | MetaboLights
GenomicsDifferential Methylation Of The TRPA1 Promoter In Pain Sensitivity: MeDIP-sequencing
Chronic pain is a global public health problem, but the underlying molecular mechanisms are not fully understood. Here we examine genome-wide DNA methylation, first in 50 identical twins discordant for heat pain sensitivity and then in 50 further unrelated individuals. Whole blood DNA methylation wa...
ORGANISM(S): Homo sapiens 
2013-12-04 | E-GEOD-52965 | biostudies-arrayexpress
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