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TranscriptomicsThe Apcmin mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS
Apc, a negative regulator of the canonical Wnt signaling pathway, is a bona-fide tumor suppressor whose loss of function results in intestinal polyposis. APC is located in a commonly deleted region on human chromosome 5q, associated with myelodysplastic syndrome (MDS) suggesting that haploinsufficie...
ORGANISM(S): Mus musculus 
2010-02-21 | E-GEOD-20352 | biostudies-arrayexpress
TranscriptomicsMusashi 2 regulates normal hematopoiesis and accelerates leukemogenesis (LK and MS12-inducible)
We demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSC), and its knockdown leads to reduced engraftment and depletion of HSCs in vivo. Overexpression of Msi2 in a mouse model increases HSC cell cycle progression and cooperates with BCR-ABL1 to induce an aggressiv...
ORGANISM(S): Mus musculus 
2010-07-21 | E-GEOD-22773 | biostudies-arrayexpress
TranscriptomicsMusashi 2 regulates normal hematopoiesis and accelerates leukemogenesis (LSK and LK)
We demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSC), and its knockdown leads to reduced engraftment and depletion of HSCs in vivo. Overexpression of Msi2 in a mouse model increases HSC cell cycle progression and cooperates with BCR-ABL1 to induce an aggressiv...
ORGANISM(S): Mus musculus 
2010-07-22 | E-GEOD-22774 | biostudies-arrayexpress
TranscriptomicsMusashi 2 regulates normal hematopoiesis and accelerates leukemogenesis (Leukemia cell lines)
We demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSC), and its knockdown leads to reduced engraftment and depletion of HSCs in vivo. Overexpression of Msi2 in a mouse model increases HSC cell cycle progression and cooperates with BCR-ABL1 to induce an aggressiv...
ORGANISM(S): Homo sapiens 
2010-07-21 | E-GEOD-22775 | biostudies-arrayexpress
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