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TranscriptomicsTranscription profiling of human umbilical vein endothelial cells treated with Interferon-gamma (IFN-g), Borrelia burgdorferi or both IFN-g and Borrelia or untreated to investigate immune responses to Lyme disease
Borrelia burgdorferi, the agent of Lyme disease, promotes pro-inflammatory changes in endothelium that lead to the recruitment of leukocytes. The host immune response to infection results in increased levels of IFN-gamma in the serum and lesions of Lyme disease patients that correlate with greater s...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6092 | biostudies-arrayexpress
TranscriptomicsKIM5 intracellular expression profiling
Microarrays were used to determine the transcriptional profile of Y. pestis that is growing inside macrophages. J774A.1 macrophage-like cells were infected with Y. pestis KIM5 and incubated in the presence of gentamicin in tissue culture media. RNA was isolated from intracellular bacteria at vari...
ORGANISM(S): Yersinia pestis 
2010-07-07 | E-GEOD-22168 | biostudies-arrayexpress
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