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TranscriptomicsGenome-wide analysis of gene expression after tyrosine or methionine/cysteine deprivation in HeLa cells
Limitation of essential amino acids, such as tyrosine or methionine/cysteine, causes upregulation of exogenous integrated transgene expression in mammalian cells. This phenomenon is mediated by histone acetylation and chromatin remodelling, since histone deacetylase (HDAC) inhibitors reproduce starv...
ORGANISM(S): Homo sapiens 
2012-07-23 | E-GEOD-35323 | biostudies-arrayexpress
ProteomicsGlobal changes in nitration levels and DNA binding profile of Trypanosoma cruzi histones induced by incubation with host extracellular matrix.
Adhesion of T. cruzi trypomastigotes to components of the extracellular matrix (ECM) is an important step in mammalian host cell invasion. We have recently described a significant increase in the tyrosine nitration levels of histones H2A and H4 when trypomastigotes are incubated with components of t...
ORGANISM(S): Trypanosoma cruzi cruzi 
2021-09-09 | PXD016313 | Pride
Histones Tyrosine nitration Trypanosoma cruzi Extracellular matrix 
TranscriptomicsTranscriptome analysis of HeLa cells upon deprivation of methionine and cysteine (Met/Cys)
We have previously shown that deprivation of essential amino acids, namely methionine/cysteine or tyrosine, leads to the transcriptional reactivation of integrated silenced transgenes, and latent HIV-1 provirus. In an effort to understand the underlying mechanisms, here we investigate the overall tr...
ORGANISM(S): Homo sapiens 
2018-07-21 | E-MTAB-6452 | biostudies-arrayexpress
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