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TranscriptomicsTranscription profiling of human gamma-secretase inhibitor-sensitive and -resistant T-ALL cell lines
Gain-of-function mutations in NOTCH1 are common in T-cell lymphoblastic leukemias making this receptor a promising target for drugs such as gamma-secretase inhibitors, which block a proteolytic cleavage required for NOTCH1 activation. However, the enthusiasm for these therapies has been tempered by ...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-5682 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of T-ALL cell lines treated with gamma-secretase inhibitor
Gain-of-function mutations in NOTCH1 are common in T-cell lymphoblastic leukemias making this receptor a promising target for drugs such as gamma-secretase inhibitors (GSI), which block a proteolytic cleavage required for NOTCH1 activation. However, the enthusiasm for these therapies has been temper...
ORGANISM(S): Homo sapiens 
2008-08-20 | E-GEOD-5716 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human T-ALL cell cultures treated with Compound E, a gamma-secretase inhibitor or vehicle only (DMSO) for 24 h
The NOTCH1 signaling pathway directly links extracellular signals with transcriptional responses in the cell nucleus and plays a critical role during T-cell development and in the pathogenesis over 50% of human T-cell lymphoblastic leukemia (T-ALL) cases. However, little is known about the transcrip...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-5827 | biostudies-arrayexpress
GenomicThe Mutational Landscape of CTCL and Sezary Syndrome.

Sezary syndrome is a leukemic and aggressive form of cutaneous T-cell lymphoma (CTCL) resulting from the malignant transformation of skin-homing central memory CD4+ T cells. To identify new genetic alterations involved in Sezary syndrome and CTCL transformation we performed whole-exome sequencing...

phs000994 | dbGaP
TranscriptomicsExpression data obtained from ALLSIL cell line
The experiment was designed in order to knock down the expression of TLX1 gene in T-ALL cell line We used microarrays to identify the gene expression signatures associated with TLX1 knock down in ALLSIL ALLSIL cell lines were infected with pLKO.1-shTLX1 and pLKO.1-luc control lentivirus. After 5 day...
ORGANISM(S): Homo sapiens 
2011-11-08 | E-GEOD-33539 | biostudies-arrayexpress
GenomicsRomidepsin and afatinib combination treatment induce synergistic anti-lymphoma effect in CTCL
Romidepsin and afatinib combination treatment induce synergistic anti-lymphoma effect in CTCL
PRJNA994103 | ENA
GenomicsNOTCH1 ChIP-Seq in HBPALL cell lines
ChIP-Seq detected global binding of NOTCH1 oncogene in a human T-Cell Leukemia Cell line. ChIP-Seq of NOTCH1 in HBALL cell lines and Whole Cell Extract (WCE) as control.
ORGANISM(S): Homo sapiens 
2014-09-07 | E-GEOD-58406 | biostudies-arrayexpress
TranscriptomicsHematopoietic Stem Cell Differentiation Regulated by a Single Ubiquitin Ligase: Substrate Complex
Hematopoietic stem cell (HSC) differentiation is regulated by cell-intrinsic and extrinsic cues. In addition to transcriptional regulation, post-translational regulation may also control HSC differentiation. To test this hypothesis, we visualized ubiquitin-regulated protein stability of a single tra...
ORGANISM(S): Mus musculus 
2010-03-07 | E-GEOD-19502 | biostudies-arrayexpress
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