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UnknownPam2CSK4-adjuvanted SARS-CoV-2 RBD nanoparticle vaccine induces robust humoral and cellular immune responses.
Not available
S-EPMC9780597 | biostudies-literature
UnknownThe Toll-Like Receptor 2 Ligand Pam2CSK4 Activates Platelet Nuclear Factor-κB and Bruton's Tyrosine Kinase Signaling to Promote Platelet-Endothelial Cell Interactions.
Not available
S-EPMC8435771 | biostudies-literature
UnknownEvaluation of different combination of pam2CSK4, poly (I:C) and imiquimod enhance immune responses to H9N2 avian influenza antigen in dendritic cells and duck.
Not available
S-EPMC9295992 | biostudies-literature
TranscriptomicsGene expression in mouse lung epithelial cells treated with synthetic TLR ligands to induce resistance
Infectious pneumonias exact an unacceptable mortality burden worldwide. Efforts to protect populations from pneumonia have historically focused on antibiotic development and vaccine-enhanced adaptive immunity. However, we have recently reported that the lungs’ innate defenses can be therapeuticall...
ORGANISM(S): Mus musculus 
2011-01-27 | E-GEOD-26864 | biostudies-arrayexpress
Genomics
Transcriptomic profiling of primary mouse B cells stimulated with MVHB4 or Pam2CSK4
PRJNA1526051 | ENA
TranscriptomicsGene expression in mouse lung homogenates treated with synthetic TLR ligands to induce resistance
Infectious pneumonias exact an unacceptable mortality burden worldwide. Efforts to protect populations from pneumonia have historically focused on antibiotic development and vaccine-enhanced adaptive immunity. However, we have recently reported that the lungs’ innate defenses can be therapeuticall...
ORGANISM(S): Mus musculus 
2011-05-01 | E-GEOD-28994 | biostudies-arrayexpress
TranscriptomicsCostimulation through costimulatory molecules (CD40 or CD86) Synergizes with TLR-2 in the Activation of Resting B Cells: A Novel BCR Independent Approach of B Cell Stimulation
Resting B cells were isolated from mice splenocytes. Briefly, single cell suspension was prepared and treated with B cell enrichment cocktail supplemented with biotinylated anti-CD43 Abs. The cells were then treated with same volume of streptavidin-magnetic beads and negatively selected on BD IMagne...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-28517 | biostudies-arrayexpress
TranscriptomicsExpression data from murine follicular dendritic cells
Germinal centers (GCs) are clusters of activated B cells built on stromal cells known as follicular dendritic cells (FDCs). In the Peyer’s patches (PPs), GCs are chronically induced by bacteria and are the major sites for generation of gut IgA immune responses. Whether FDCs directly contribute to ...
ORGANISM(S): Mus musculus 
2010-07-30 | E-GEOD-19401 | biostudies-arrayexpress
UnknownToll-like receptor 2 ligand and interferon-γ suppress anti-tumor T cell responses by enhancing the immunosuppressive activity of monocytic myeloid-derived suppressor cells.
Not available
S-EPMC5739553 | biostudies-literature
UnknownThe molecular basis for recognition of bacterial ligands at equine TLR2, TLR1 and TLR6.
Not available
S-EPMC3716717 | biostudies-literature
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