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ProteomicsTargeting ubiquitin-independent proteasome with small molecule increases susceptibility in pan-KRAS mutant cancers
Despite advances in the development of direct KRAS inhibitors, KRAS-mutant cancers continue to exhibit resistance to the currently available therapies. Here, we identified REGγ as a mutant KRAS-associated factor that enhances REGγ transcription through the KRAS intermediate NRF2, suggesting that the...
ORGANISM(S): Homo Sapiens 
2025-01-01 | PXD059364 |
UnknownPan-conserved segment tags identify ultra-conserved sequences across assemblies in the human pangenome.
Not available
S-EPMC10475782 | biostudies-literature
MetabolomicsSupplementation of Bacillus sp. DU-106 reduces hypercholesterolemia and ameliorates gut dysbiosis in high-fat diet rats

Gut microbiota modulation by a probiotic is a novel therapy for hypercholesterolemia mitigation. This study initially investigated the potential hypocholesterolemic effect of Bacillus sp. DU-106 in hypercholesterolemic rats and explored its potential relation with gut microbiota. Sprague-Dawley r...

2021-04-08 | MTBLS1168 | MetaboLights
TranscriptomicsEffects of pregnancy on hepatic gene expression in CYP2D6-humanized mice
Hepatic drug metabolism plays a key role in determining drug response and safety. Studies of drug metabolism generate valuable information about regulation of genes encoding drug-metabolizing enzymes and enzyme functions that are critical in developing dosing guideline. However, current knowledge is...
ORGANISM(S): Mus musculus 
2014-12-04 | E-GEOD-50166 | biostudies-arrayexpress
UnknownInhibitors of cullin-RING E3 ubiquitin ligase 4 with antitumor potential.
Not available
S-EPMC7923628 | biostudies-literature
UnknownPan-cancer analysis of whole genomes.
Not available
S-EPMC7025898 | biostudies-literature
UnknownA Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition.
Not available
S-EPMC3968867 | biostudies-literature
UnknownPan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with metastatic colorectal cancer.
Not available
S-EPMC10220270 | biostudies-literature
UnknownExosomal circSPIRE1 mediates glycosylation of E-cadherin to suppress metastasis of renal cell carcinoma.
Not available
S-EPMC10238271 | biostudies-literature
UnknowncircPLIN2 promotes clear cell renal cell carcinoma progression by binding IGF2BP proteins and miR-199a-3p.
Not available
S-EPMC9734136 | biostudies-literature
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