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TranscriptomicsExpression data from WT and TCF-1-deficient memory CD8 T cells
TCF-1 is an HMG family transcription factor which is known to be activated by the canonical Wnt signaling pathway and modulated by other signals such as those derived from T cell receptor. We found that during CD8 T cell responses, TCF-1 deficiency impaired long-term maintenance of antigen-specific ...
ORGANISM(S): Mus musculus 
2010-10-04 | E-GEOD-20754 | biostudies-arrayexpress
TranscriptomicsGene expression data from LCMV-specific WT and Tcf7-/- follicular T helper cells
We did microarray experiments to elucidate the transcriptome changes due to TCF-1 deficiency in Tfh cells. These data clearly demonstrate that Tfh-associated genes were down-regulated in TCF-1-null Tfh cells, whereas Th1-associated signatures were up-regulated, indicating that TCF-1 initiates the Tf...
ORGANISM(S): Mus musculus 
2015-07-24 | E-GEOD-65693 | biostudies-arrayexpress
MetabolomicsAge-, sex- and proximal-distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates.

The incidence of intestinal diseases increases with age, but the regulators of gut aging and the molecules linking gut aging and diseases remain largely unknown. By profiling the transcriptome, proteome, phosphoproteome and metabolome of 104 Macaca fascicularis large intestinal tissues, ...

2023-12-14 | MTBLS7612 | MetaboLights
MetabolomicsA synthetic antibiotic class with a deeply-optimized design for overcoming bacterial resistance

The lack of new drugs that are effective against antibiotic-resistant bacteria has caused increasing concern in global public health. Based on this study, we report development of a modified antimicrobial drug through structure-based drug design (SBDD) and modular synthesis. The optimal modified ...

2024-07-03 | MTBLS10516 | MetaboLights
ProteomicsStructural insights into caspase ADPR-deacylization catalyzed by a bacterial effector and host calmodulin
identification of CopC-catalyzed ADPR-deacylization modification site of caspase-3/-7/-8/-9
ORGANISM(S): Homo Sapiens 
2022-08-10 | PXD035969 |
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