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MetabolomicsLow-Protein Diet Enhances Anti-Tumor Immunity in Pancreatic Cancer through Microbiota-Derived Uridine Diphosphate-Galactose
Low-protein diets (LPD) have been linked to improved metabolic health, but their role in pancreatic ductal adenocarcinoma (PDAC) immunotherapy remains unclear. Here we show that an LPD suppresses PDAC progression in male mice by remodeling the gut microbiota and activating anti-tumor immunity. LPD p...
2026-07-09 | MTBLS14989 | MetaboLights
MetabolomicsSpatial multi-omics inference of diabetes mellitus triggering pancreatic cancer growth through cholesterol-induced neutrophil extracellular traps

Spatial multi-omics inference of diabetes mellitus triggering pancreatic cancer growth through cholesterol-induced neutrophil extracellular traps

2025-11-26 | MTBLS12782 | MetaboLights
TranscriptomicsMultiple Salivary Biomarkers for Early Detection of Pancreatic Cancer
Pancreatic cancer is the fourth leading cause of cancer death. Lack of early detection technology for pancreatic cancer invariably leads to a typical clinical presentation of incurable disease at initial diagnosis. Oral fluid (saliva) meets the demand for non-invasive, accessible, and highly efficie...
ORGANISM(S): Homo sapiens 
2008-12-30 | E-GEOD-14245 | biostudies-arrayexpress
MetabolomicsThe Impact of Ethnicity and Intra-Pancreatic Fat on the Postprandial Metabolome Response to Whey Protein in Overweight Asian Chinese and European Caucasian Women with Prediabetes
The 'Thin on the Outside Fat on the Inside' TOFI_Asia study found Asian Chinese to be more susceptible to Type 2 Diabetes (T2D) compared to European Caucasians matched for gender and body mass index (BMI). This was influenced by degree of visceral adipose deposition and ectopic fat accumulation in k...
2022-10-12 | MTBLS5568 | MetaboLights
ProteomicsChronic pancreatitis vs pancreatic cancer LC-MS
Age-standardized incidence rates for pancreatic cancer (PC) in men have increased by 25% from 1957 to 2011 in Finland. The average age of diagnosis for PC is 69 years in Nordic males, whereas the average age of diagnosis of chronic pancreatitis (CP) is 40-50 years, but the cases overlap in age. By r...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-08-31 | MSV000082883 | MassIVE
TranscriptomicsGenome-wide analysis of promoter methylation in pancreatic adenocarcinoma
Methylation profiles of pancreatic adenocarcinoma cell lines were compared with normal pancreatic ductal tissues Methylated CpG island amplification was followed by CpG island microarray
ORGANISM(S): Homo sapiens 
2011-06-04 | E-GEOD-29723 | biostudies-arrayexpress
TranscriptomicsMicroarray expression profile analysis of circular RNAs in human pancreatic ductal adenocarcinoma
To explore the potential involvement of circular RNAs (circRNAs) in pancreatic ductal adenocarcinoma (PDAC) oncogenesis, we conducted circRNA profiling in six pairs of human PDAC and adjacent normal tissue by microarray. Our results showed that clusters of circRNAs were aberrantly expressed in PDAC ...
ORGANISM(S): Homo sapiens 
2015-11-20 | E-GEOD-69362 | biostudies-arrayexpress
TranscriptomicsPancreatic cancer biomarkers in mouse saliva
This is a pilot study. We are trying to detect potential salivary biomarkers in mice with a pancreatic tumor. Global gene expression profiling has shown great promise in high-throughput biomarker discovery for early disease detection in body fluids such as saliva, which is accessible, cost-effectiv...
ORGANISM(S): Mus musculus 
2013-06-12 | E-GEOD-47811 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing of human pancreatic adenocarcinoma cancer tissues
RNA-seq profiling was conducted on clinically-annotated human pancreatic adenocarcinoma cancer tissues We measured the transcriptome in 51 clinically-annotated human pancreatic adenocarcinoma cancer tissues
ORGANISM(S): Homo sapiens 
2016-06-11 | E-GEOD-79668 | biostudies-arrayexpress
MetabolomicsMetabolic profiling of induced acute pancreatitis and pancreatic cancer progression in a mutant Kras mouse model
Not available
ORGANISM(S): Mus musculus 
ST002202 | MetabolomicsWorkbench
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