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MetabolomicsEMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer

The involvement of membrane-bound solute carriers (SLCs) in neoplastic transdifferentiation processes is poorly defined. Here, we examined changes in the SLC landscape during epithelial-mesenchymal transition (EMT) of pancreatic cancer cells. We show that two SLCs from the organic anion...

2021-10-15 | MTBLS1925 | MetaboLights
TranscriptomicsImage based identification and targeting of cancer stem cells in pancreatic adenocarcinoma
Pancreatic intraepithelial neoplasia (PanIN) is a premalignant lesion that can progress to pancreatic ductal adenocarcinoma, a highly lethal malignancy marked by its late stage at clinical presentation and profound drug resistance. Here we developed novel fluorescent reporter mice that show that the...
ORGANISM(S): Mus musculus 
2016-06-15 | E-GEOD-73312 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of mouse pancreatic beta-cells, embryonic stem cells and 10 other normal adult tissues.
To gain insights into how pancreatic beta-cells are programmed in vivo, we profiled key histone methylations (H3K4/K27me3) in embryonic stem cells, multipotent progenitors of the nascent embryonic pancreas, purified beta-cells, and 10 other adult tissues (all under normal, untreated conditions). For...
ORGANISM(S): Mus musculus 
2010-03-19 | E-TABM-877 | biostudies-arrayexpress
ProteomicsPancreatic cells spectral library by the DIA strategy and the phenotype analysis of gemcitabine-sensitive
Data-independent acquisition (DIA)-mass spectrometry (MS) based proteome strategies is increasingly used for detecting and validating protein biomarkers and therapeutic targets. Here, by in-depth proteome analysis of 7 pancreatic cell lines, we built a pancreas-specific mass spectrum library contain...
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD032263 | Pride
Pancreatic cells spectral library 
TranscriptomicsPancreatic cancer stem-like cells display aggressive behavior mediated via activation of FoxQ1
A microarray approach was used to measure and compare whole genome expression in non-sorted cell population and in subsets of cultured cells, including stem-like cancer cell and non-stem like cancer cell populations, MiaPaCa-2 pancreatic cancer cells from culture were sorted by Fluorescence Activate...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-GEOD-51971 | biostudies-arrayexpress
ProteomicsMulti-omics Study Reveals the Synergistic Anti-tumor Effects of Aspirin and Gemcitabine-based Chemotherapy on Pancreatic Cancer and the Underlying Mechanism
Pancreatic cancer is a highly malignant tumor that is well known for its poor prognosis. It has been reported that aspirin can reduce the risk of various cancers, but the potential role of aspirin and gemcitabine in pancreatic cancer pathogenesis and chemotherapy has not been studied. Therefore, we ...
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD031910 | Pride
Pancreatic cancer Multi-omics Synergistic effect Aspirin Gemcitabine 
TranscriptomicsGene expression of pancreatic cancer cells
Global gene expression profiling on replicates of 9 pancreatic cancer cell lines (L3.6pl, BxPC3, CFPAC, SU8686, Panc-1, Hs766T, AsPC1, MIAPaca-2, MPanc 96) and normal HPDE cells was performed to elucidate multi-drug sensitivity/ resistance. Keywords: D microarray (Illumina human 2) Duplicates of 9 ...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-15550 | biostudies-arrayexpress
TranscriptomicsImage based identification and targeting of cancer stem cells in pancreatic adenocarcinoma (PDAC)
Purpose: The goals of this study were to identify quantitative gene expression differences between wild type, Musashi1 null, Msuashi2 null and Musashi1/Musashi2 null MIAPaCa2 pancreatic cancer cells mRNA profiles of MIA PaCa-2 cancer cells were generated by deep sequencing, in triplicate, using Ill...
ORGANISM(S): Homo sapiens 
2016-06-15 | E-GEOD-75797 | biostudies-arrayexpress
TranscriptomicsS100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells [HG-U133_Plus_2]
We and others have shown that S100P is highly upregulated during the progression of pancreatic cancer. We used microarrays to look at the target genes regulated by S100P in the pancreatic cancer cell line Panc1. Keywords: Gene overexpression We generated stable cell lines by introducing control vec...
ORGANISM(S): Homo sapiens 
2013-08-15 | E-GEOD-19278 | biostudies-arrayexpress
TranscriptomicsExpression Data from 22 human pancreatic cancer cell lines grown in triplicates +/- MEK inhibitor CI-1040
Analysis of mRNA profiles after MEK1/2 inhibition in human pancreatic cancer cell lines reveals pathways involved in drug sensitivity. We used microarrays to find gene expression patterns associated with drug response and also identified genes regulated by the MAP kinase pathway 22 pancreatic cell l...
ORGANISM(S): Homo sapiens 
2013-04-04 | E-GEOD-45757 | biostudies-arrayexpress
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