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MetabolomicsIntegrated omics analysis of pathogenic host responses during pandemic H1N1 influenza virus infection: the crucial role of lipid metabolism
Pandemic influenza viruses modulate pro-inflammatory responses that can lead to immunopathogenesis. We present an extensive and systematic profiling of lipids, metabolites and proteins in respiratory compartments of ferrets infected with either 1918 or 2009 human pandemic H1N1 influenza viruses. Int...
2016-05-11 | MTBLS196 | MetaboLights
TranscriptomicsHosts responses in critical disease caused by pandemic H1N1
Critical disease caused by the new 2009 pandemic influenza virus (nvH1N1) is a challenge for physicians and scientist. As evidenced in SARS and H5N1, the development of an effective immune response plays a key role to overcome viral diseases. We studied host`s gene expression signatures, cytokine a...
ORGANISM(S): Homo sapiens 
2011-05-05 | E-GEOD-21802 | biostudies-arrayexpress
MetabolomicsMetabolomic profiling of influenza: a 2009 pandemic H1N1 influenza in lean and obese mice (via Urine)
Not available
ORGANISM(S): Mus musculus 
ST000071 | MetabolomicsWorkbench
MetabolomicsMetabolomic profiling of influenza: a 2009 pandemic H1N1 influenza in lean and obese mice (via tissue)
Not available
ORGANISM(S): Mus musculus 
ST000070 | MetabolomicsWorkbench
Transcriptomics1918 pandemic influenza virus and pneumococcus co-infection results in activation of coagulation and widespread pulmonary microvascular thrombosis in mice and humans
To study the effects of secondary bacterial infection during 1918 pandemic H1N1 influenza virus infection, BALB/c mice were inoculated with the fully reconstructed 1918 influenza virus followed by inoculation with pneumococcus 72h later. To study the effects of secondary bacterial infection during 1...
ORGANISM(S): Mus musculus 
2015-09-20 | E-GEOD-70445 | biostudies-arrayexpress
MetabolomicsMetabolomic profiling of influenza: a 2009 pandemic H1N1 influenza in lean and obese mice (via blood and tissue)
Not available
ORGANISM(S): Mus musculus 
ST000069 | MetabolomicsWorkbench
TranscriptomicsComparative transcriptomic analysis of acute host responses during 2009 pandemic H1N1 influenza infection in mouse, macaque, and swine
This SuperSeries is composed of the following subset Series: GSE35738: 2009 pandemic H1N1 virus causes disease and upregulation of genes related to inflammatory and immune response, cell death, and lipid metabolism in pigs GSE40088: Comparative transcriptomic analysis of acute host responses during ...
ORGANISM(S): Mus musculus 
2012-08-13 | E-GEOD-40092 | biostudies-arrayexpress
TranscriptomicsEarly CCL2 and CXCL10 chemokine expression correlates with lung pathology in Pandemic H1N1 Influenza A infection
Background: Pandemic H1N1 influenza A is a newly emerging strain of human influenza that is easily transmitted between people and has spread globally to over 116 countries. Human infection leads to symptoms ranging from mild to severe with lower respiratory complications observed in a small but sign...
ORGANISM(S): Mustela putorius furo 
2010-04-12 | E-GEOD-17079 | biostudies-arrayexpress
TranscriptomicsGenome-wide mRNA expression profiles induced by infection with the pandemic and seasonal influenza A viruses in macrophages
Infection with pandemic A/H1N1 influenza virus induces high levels of circulating and lung pro-inflammatory cytokines and chemokines in experimental models and humans. These inflammatory mediators contribute to poor clinical outcomes of this infection. To compare the regulation of inflammatory respo...
ORGANISM(S): Homo sapiens 
2012-06-09 | E-GEOD-36012 | biostudies-arrayexpress
TranscriptomicsComparative transcriptomic analysis of acute host responses during 2009 pandemic H1N1 influenza infection in mouse, macaque, and swine (swine dataset)
Background: The 2009 pandemic H1N1 influenza virus emerged in swine and quickly became a major global health threat. In mouse, non-human primate, and swine infection models, the pH1N1 virus efficiently replicates in the lung and induces pro-inflammatory host responses; however, whether similar or di...
ORGANISM(S): Sus scrofa 
2012-09-12 | E-GEOD-40847 | biostudies-arrayexpress
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