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TranscriptomicsRenal Cell Carcinomas in Vinylidene Chloride Exposed Male B63FC1 Mice Are Characterized by Oxidative Stress and TP53 Overexpression
Vinylidene Chloride has been widely used in the production of plastics and flame retardants. Exposure of B6C3F1 to VDC in the 2-year National Toxicology Program carcinogenicity bioassay resulted in a dose-dependent increase in renal cell hyperplasias, adenomas, and carcinomas (RCCs). Global gene exp...
ORGANISM(S): Mus musculus 
2015-12-21 | E-GEOD-67320 | biostudies-arrayexpress
TranscriptomicsGenomic profiling reveals unique molecular alterations in hepatoblastomas and adjacent hepatocellular carcinomas in B3C3F1 mice
The cell of origin of hepatoblastoma in humans and mice (HB) is unknown; it has been hypothesized to be a transformed hepatocyte, an oval cell, or a multipotent hepatic progenitor cell. In mice, the current dogma is that HBs arise within hepatocellular neoplasms as a result of further transformation...
ORGANISM(S): Mus musculus 
2015-09-01 | E-GEOD-67316 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression profiling of hepatocellular carcinomas in B6C3F1 mice induced by Ginkgo biloba extract by gavage for two years
Ginkgo biloba leaf extract (GBE) has been used for centuries in traditional Chinese medicine and today is used as an herbal supplement for various indications such as improving neural function, anti-oxidant and anti-cancer effects. As part of the herbal supplement industry, these compounds are large...
ORGANISM(S): Mus musculus 
2012-12-07 | E-GEOD-29813 | biostudies-arrayexpress
TranscriptomicsGlobal Differential Gene Expression Analysis of Spontaneous Lung Tumors in B6C3F1 Mice: Comparison to Human Non-Small Cell Lung Cancer
Introduction: Lung cancer is the leading cause of cancer-related death in people. There are several chemically induced and genetically modified mouse models used to study lung cancer. We hypothesized that spontaneous murine (B6C3F1) lung tumors can serve as a model to study human non-small cell lung...
ORGANISM(S): Mus musculus 
2012-06-21 | E-GEOD-31013 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression profiling of spontaneous mesotheliomas in F344N rats
Aged male Fischer 344/N rats are prone to developing spontaneous peritoneal mesotheliomas, which arise predominantly from the tunica vaginalis of the testes. A definitive cause for the predominance of this neoplasm in F344/N rats is unknown. Investigation of the molecular alterations that occur in s...
ORGANISM(S): Rattus norvegicus 
2013-09-06 | E-GEOD-47581 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression profiling of spontaneous hepatocellular carcinoma in B6C3F1 mice: Similarities in the molecular landscape to human liver cancer.
Hepatocellular carcinoma (HCC) is an important cause of morbidity and mortality worldwide. Although the risk factors of human HCC are well known, the molecular characterization of this disease is complex, and treatment options in general remain poor. The use of rodent models to study human cancer ha...
ORGANISM(S): Mus musculus 
2011-06-06 | E-GEOD-26538 | biostudies-arrayexpress
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