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TranscriptomicsTranscription profiling of human fibroblast cell line CCD27SK before and after pluripotent reprogramming by lentiviral-mediated insertion of SOX2 C-MYC and TCL-1A
Reprogramming of somatic cells to pluripotency, thereby creating induced pluripotent stem (iPS) cells, promises to boost cellular therapy. Most instances of direct reprogramming have been achieved by forced expression of defined exogenous factors using multiple viral vectors. The most used four tran...
ORGANISM(S): Homo sapiens 
2010-10-26 | E-MEXP-2422 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD133 and CD34 positive hematopoietic stem cells imuno-magnetically isolated from bone marrow and umbilical cord blood
Expression Profiling of CD133 and CD34 positive Hematopoietic Stem Cells imuno-magnetically isolated from Bone Marrow and Umbilical Cord Blood
ORGANISM(S): Homo sapiens 
2009-07-31 | E-MEXP-1890 | biostudies-arrayexpress
TranscriptomicsCultured human adipose tissue pericytes and mesenchymal stromal cells display a very similar gene expression profile
Mesenchymal stromal cells (MSCs) are cultured cells that can give rise to mature mesenchymal cells under appropriate conditions, and secrete a number of biologically relevant molecules that may play an important role in regenerative medicine. Evidence indicates that pericytes (PCs) correspond to mes...
ORGANISM(S): Homo sapiens 
2015-07-22 | E-GEOD-67747 | biostudies-arrayexpress
TranscriptomicsGenome-wide gene expression profiling reveals unsuspected molecular alterations in Pemphigus Foliaceus
Pemphigus foliaceus (PF) is a complex autoimmune disease characterized by bullous skin lesions and the presence of antibodies against desmoglein 1. In this study we sought to contribute to a better understanding of the molecular processes in endemic PF, since the identification of factors that parti...
ORGANISM(S): Homo sapiens 
2014-01-08 | E-GEOD-53873 | biostudies-arrayexpress
TranscriptomicsPotential Roles of miR-29a in the Molecular Pathophysiology of T-Cell Acute Lymphoblastic Leukemia
The miR-29 family is an important player in the molecular pathophysiology of distinct types of cancer, with roles that seems to depend on cellular context. Reduced miR-29 levels are associated with more aggressive disease and its overexpression in cancer and leukemic cell lines inhibits proliferatio...
ORGANISM(S): Homo sapiens 
2013-09-01 | E-GEOD-48063 | biostudies-arrayexpress
TranscriptomicsMesenchymal Stem Cells Promote the Sustained Expression of CD69 on Activated T-lymphocytes: Roles of Canonical and Non-Canonical NF-κB Signaling
Mesenchymal stem cells (MSCs) are known to induce the conversion of activated T-cells into regulatory T-cells in vitro. The marker CD69 is a target of canonical NF-κB signaling and is transiently expressed upon activation; however, stable CD69 expression defines cells with immunoregulatory propertie...
ORGANISM(S): Homo sapiens 
2011-08-02 | E-GEOD-31153 | biostudies-arrayexpress
TranscriptomicsHOX genes: potential candidates furthering the development of larynx squamous cell carcinoma.
Larynx squamous cell carcinoma (LSCC) is the second most aggressive cancer from head and neck (HSCC). Survival of LSCC patients has been found worsening, albeit significant advances in technology and therapeutics were made. We sought to clarify new genetic targets driven the development of LSCC. Ana...
ORGANISM(S): Homo sapiens 
2014-12-25 | E-GEOD-59102 | biostudies-arrayexpress
TranscriptomicsSelective Targeting of the Proliferating Compartment in Chronic Lymhocytic Leukemia by Inhibition or Downregulation of Aurora Kinases
Chronic lymphocytic leukemia (CLL) B-cells receive signals from the lymph node and bone marrow (BM) microenvironments that regulate their survival and proliferation. These signals and the pathways that propagate them to the interior of the cell represent potential targets for therapeutic interventio...
ORGANISM(S): Homo sapiens 
2011-07-25 | E-GEOD-30896 | biostudies-arrayexpress
TranscriptomicsIL-27, PXN, CXCR4, GZMA, PRF1 and Foxp3 genes are differentially expressed in CD4+ T cells of HTLV-1-infected individuals.
HTLV-1 preferentially infects CD4+ T cells and these cells play a central role in HTLV-1 infection. In this study, we investigated the global gene expression profile of circulating CD4+ T cells from distinct clinical status of HTLV-1-infected individuals in regard to Tax expression levels. CD4+ T ce...
ORGANISM(S): Homo sapiens 
2013-06-01 | E-GEOD-38537 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of T cell subsets from MS patients undergoing autologous hematopoietic stem cell transplantation reveals significant changes in immune function
Multiple sclerosis is an immune mediated disease of the central nervous system. High-dose immunosuppression therapy followed by autologous hematopoietic stem cell transplantation (HDI/AHSCT) has emerged in the past few years as a new treatment strategy in patients with severe MS and refractory to co...
ORGANISM(S): Homo sapiens 
2011-11-03 | E-GEOD-32988 | biostudies-arrayexpress
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