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TranscriptomicsIn vitro cultured H7 human embryonic stem cells (WiCell) and H7-derived downstream early mesoderm progenitors
Stem-cell differentiation to desired lineages requires navigating alternating developmental paths that often lead to unwanted cell types. Hence, comprehensive developmental roadmaps are crucial to channel stem-cell differentiation toward desired fates. To this end, here, we map bifurcating lineage c...
ORGANISM(S): Homo sapiens 
2016-08-02 | E-GEOD-85066 | biostudies-arrayexpress
TranscriptomicsLongitudinal scRNA-Seq of immune cells from GL261 murine brain Tumors and MHC class II deficient tumor-mircoenvironments
Longitudinal phenotyping of T cells and myeloid cells in early (day 14) and late (day26) GL261 tumors. Single cell RNA sequencing of CD45+ immune cell from intracranial murine GL261-SIINFEKL tumors 20 days after inoculation. SIINFEKL-reactive T cells were sorted based on dextramer staining. Using t...
ORGANISM(S): Mus musculus 
2023-01-19 | E-MTAB-12523 | biostudies-arrayexpress
TranscriptomicsscRNA-seq of PBMC cells sorted into CD3+/CD19+ and CD3-CD19- buckets from Omenn syndrome patients and healthy controls
In this study, we sought to extend knowledge of lymphocyte development by studying patients with classical Omenn syndrome or T-B- SCID. to gain further insight into pathomechanism, we undertook single cell studies of cryopreserved peripheral blood mononuclear cells from patients with Omenn syndrome ...
ORGANISM(S): Homo sapiens 
2024-06-06 | E-MTAB-12283 | biostudies-arrayexpress
TranscriptomicsPaired scRNAseq of the and non-hematopoietic and the immune microenvironment of aspirates from newly diagnosed Multiple Myeloma patients versus non-cancer controls
By generating a paired single cell RNA-sequencing database of the tumor niche from 10 newly diagnosed MM patients, we created a unique dataset allowing the in-depth analyses of stromal-immune interactions within the tumor microenvironment. Using this database, we identified the presence of inflammat...
ORGANISM(S): Homo sapiens 
2020-09-30 | E-MTAB-9139 | biostudies-arrayexpress
TranscriptomicsAn IL-1β driven neutrophil-stromal cell axis fosters a BAFF-rich microenvironment in multiple myeloma
Neutrophils are the most abundant nucleated cell type in the bone marrow. A pro-tumor bias in this cell type may have implications for bone-marrow residing malignancies, such as multiple myeloma. Here, we generated single cell transcriptomic overviews of the entire myeloid compartment, including the...
ORGANISM(S): Homo sapiens 
2023-03-31 | E-MTAB-12760 | biostudies-arrayexpress
TranscriptomicsscRNA-seq of human PBMCs and tumor-infiltrated lymphocytes from melanoma patients analysed prior to checkpoint inhibitor treatment
We performed single-cell RNA-sequencing of tumor immune infiltrates and matched peripheral blood mononuclear cells of checkpoint inhibitor (CPI)-naive stage III-IV metastatic melanoma patients. After sample collection, the same patients received CPI-treatment and their response was assessed.
ORGANISM(S): Homo sapiens 
2024-04-08 | E-MTAB-13770 | biostudies-arrayexpress
TranscriptomicsscRNAseq of the bone marrow immune microenvironment in control and 5TGM1 myeloma-bearing C57Bl/6 and KaLwRij mice
We hypothesized that the immune microenvironment of the bone marrow influences the progression of myeloma outgrowth in the 5TGM1 transfer model of multiple myeloma. Therefore we sorted bone marrow T, B, NK, neutrophils, and monocytes/macrophages from control and tumor-bearing C57Bl/6 and KaLwRij mic...
ORGANISM(S): Mus musculus 
2023-02-23 | E-MTAB-12616 | biostudies-arrayexpress
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