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UnknownpanX: pan-genome analysis and exploration.
Not available
S-EPMC5758898 | biostudies-literature
UnknownNew Panx-1 Blockers: Synthesis, Biological Evaluation and Molecular Dynamic Studies.
Not available
S-EPMC9103715 | biostudies-literature
UnknownDesign, Synthesis and Pharmacological Evaluation of New Quinoline-Based Panx-1 Channel Blockers.
Not available
S-EPMC9916356 | biostudies-literature
ProteomicspiRNA-guided co-transcriptional silencing coopts nuclear export factors
The PIWI-interacting RNA (piRNA) pathway is a small RNA-based immune system that controls the expression of transposons and maintains genome integrity in animal germlines1,2. In Drosophila, piRNA-guided silencing is achieved, in part, via co-transcriptional repression of transposons by Piwi. This de...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2019-06-20 | PXD011415 | Pride
Pirna transposons piwi nuclear export 
UnknownPatch-clamp coordinated spectroscopy shows P2X2 receptor permeability dynamics require cytosolic domain rearrangements but not Panx-1 channels.
Not available
S-EPMC2575328 | biostudies-literature
ProteomicsA Pandas complex adapted for piRNA-guided transposon silencing and heterochromatin formation, Panx-IP-MS
The repression of transposons by the Piwi-interacting RNA (piRNA) pathway is essential to protect animal germ cells. In Drosophila ovaries, Panoramix (Panx) enforces transcriptional silencing by binding to the target-engaged Piwi-piRNA complex, although the precise mechanisms by which this occurs re...
ORGANISM(S): Drosophila Melanogaster 
2019-08-06 | PXD014926 |
GenomicspiRNA-guided co-transcriptional silencing coopts nuclear export factors
The PIWI-interacting RNA (piRNA) pathway is a small RNA-based immune system that controls the expression of transposons and maintains genome integrity in animal germlines1,2. In Drosophila, piRNA-guided silencing is achieved, in part, via co-transcriptional repression of transposons by Piwi. This de...
ORGANISM(S): Drosophila melanogaster 
2019-06-20 | GSE121661 | GEO
TranscriptomicsNuclear RNA export factor variant initiates piRNA-guided co-transcriptional silencing
PIWI-interacting RNAs (piRNAs) are germline-specific small RNAs that form effector complexes with PIWI proteins (Piwi–piRISC complexes) to preserve genomic integrity by repressing transposable elements (TEs). Among PIWI-clade proteins in Drosophila, Piwi transcriptionally silences its targets via he...
ORGANISM(S): Drosophila melanogaster 
2019-07-09 | GSE131950 | GEO
UnknownInhibition of Schwann cell pannexin 1 attenuates neuropathic pain through the suppression of inflammatory responses.
Not available
S-EPMC9531429 | biostudies-literature
UnknownAstrocyte Pannexin 1 Suppresses LPS-Induced Inflammatory Responses to Protect Neuronal SH-SY5Y Cells.
Not available
S-EPMC8406772 | biostudies-literature
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