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TranscriptomicsTranscription profiling of human freshly isolated PPARg and RARa ligand treated dendritic cells
Our data indicated that activation of the PPARg nuclear receptor induces a retinoid response in human dendritic cells. In order to assess the contribution of retinoid signaling to the PPARg response we decided to use a combination of pharmacological activators and inhibitors of these pathways. Cells...
ORGANISM(S): Homo sapiens 
2009-04-25 | E-GEOD-5679 | biostudies-arrayexpress
TranscriptomicsLicensing of PPARg-regulated gene expression by IL-4-induced alternative macrophage activation
This SuperSeries is composed of the following subset Series: GSE16385: Expression data from human macrophages GSE16386: Expression data from human alternatively activated macrophages GSE25088: PPARg and IL-4-induced gene expression data from wild-type and STAT6 knockout mouse bone marrow-derived mac...
ORGANISM(S): Mus musculus 
2010-11-18 | E-GEOD-16387 | biostudies-arrayexpress
TranscriptomicsExpression data from human macrophages
Human CD14 positive monocytes were purified from healthy volunteers’ blood and cultured in vitro for 4, 12, 24, 72 hours. While culturing, macrophages were activated alternatively with interleukin-4 (IL-4 100 ng/ml) or classically with interferon-gamma (IFNg 100 ng/ml)+tumor necrosis factor (TNF 50 ...
ORGANISM(S): Homo sapiens 
2010-11-18 | E-GEOD-16385 | biostudies-arrayexpress
TranscriptomicsPPARg and IL-4-induced gene expression data from PPARg +/- LysCre and PPARg fl/- LysCre mouse bone marrow-derived alternatively activated macrophages and immature dendritic cells (iDCs)
Conditional macrophage-specific PPARg knockout mice were generated on C57Bl/6 background by breeding PPARg fl/- (one allele is floxed, the other is null) and lysozyme Cre transgenic mice. PPARg and IL-4 signaling was analyzed on bone marrow-derived macrophages. Bone marrow of 4 mice per group was is...
ORGANISM(S): Mus musculus 
2010-11-18 | E-GEOD-25125 | biostudies-arrayexpress
TranscriptomicsExpression data from human alternatively activated macrophages
Human CD14 positive monocytes were purified from healthy volunteers’ blood and cultured in vitro for 6 hours. While culturing, macrophages were activated alternatively with interleukin-4 (IL-4 100 ng/ml). Simultaneously, macrophages were also treated with vehicle (DMSO:ethanol) or 1uM synthetic PPAR...
ORGANISM(S): Homo sapiens 
2010-11-18 | E-GEOD-16386 | biostudies-arrayexpress
TranscriptomicsPPARg and IL-4-induced gene expression data from wild-type and STAT6 knockout mouse bone marrow-derived macrophages
C57Bl/6 wild-type and STAT6 KO mice were used to study PPARg and IL-4 signaling. Bone marrow of 3 mice per group was isolated and differentiated to macrophages with M-CSF (20 ng/ml). 20 ng/ml IL-4 was used to induce alternative macrophage activation and 1 uM Rosiglitazone (RSG) was used to activate ...
ORGANISM(S): Mus musculus 
2010-11-18 | E-GEOD-25088 | biostudies-arrayexpress
TranscriptomicsPPARg and IL-4-induced gene expression data from PPARg +/- LysCre and PPARg fl/- LysCre mouse bone marrow-derived macrophages
Conditional macrophage-specific PPARg knockout mice were generated on C57Bl/6 background by breeding PPARg fl/- (one allele is floxed, the other is null) and lysozyme Cre transgenic mice. PPARg and IL-4 signaling was analyzed on bone marrow-derived macrophages. Bone marrow of 3 mice per group was is...
ORGANISM(S): Mus musculus 
2010-11-18 | E-GEOD-25123 | biostudies-arrayexpress
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