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TranscriptomicsConserved molecular interactions within MYST-ING acetyltransferase complexes that regulate cell proliferation
This SuperSeries is composed of the following subset Series: GSE33007: Genome-wide map of HBO1 in cancer derived human cell line GSE33220: Effects of the JADE-HBO1 complex on gene expression Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-03-15 | E-GEOD-33221 | biostudies-arrayexpress
TranscriptomicsA critical role of microRNAs in human pulmonary arterial hypertension. miR-204: a novel therapeutic target
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2010-12-16 | E-GEOD-21284 | biostudies-arrayexpress
GenomicsChIP-seq of MYST acetyltransferases
Histone acetyltransferases (HAT) assemble into multisubunit complexes in order to target distinct lysine residues on nucleosomal histones. Here, we characterize native HAT complexes assembled by the BRPF-family of scaffold proteins. Their PHD-ZnKnuckle-PHD domain is essential for binding chromatin...
ORGANISM(S): Homo sapiens 
2013-10-09 | E-GEOD-47190 | biostudies-arrayexpress
TranscriptomicsUBF Is An Epigenetic Factor Required For Ribosomal RNA Gene Activity And Preinitiation Complex Assembly But Not For Nucleolar Body Formation
Upstream Binding Factor (UBF) is a unique multi-HMGB-box protein first identified as a co-factor in RNA polymerase I (RPI/PolI) transcription. However, its poor DNA sequence selectivity and its ability to generate nucleosome-like nucleoprotein complexes suggest a more generalized role in chromatin s...
ORGANISM(S): Mus musculus 
2014-08-19 | E-GEOD-55450 | biostudies-arrayexpress
GenomicsChIP-seq of MYST acetyltransferases in RKO cell line
Genome-wide mapping of MYST acetyltransferase subunit BRPF3 in RKO synchronised cells. Genome-wide mapping of MYST acetyltransferase subunit BRPF3 in RKO synchronised cells.
ORGANISM(S): Homo sapiens 
2016-02-05 | E-GEOD-63722 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver from wild type and Wrn mutant animals with or without vitamin C treatment
Werner syndrome (WS) is a rare disorder characterized by the premature onset of a number of age-related diseases. The gene responsible for WS is believed to be involved in different aspects of transcription, replication, and/or DNA repair. We generated a mouse model with a deletion in the helicase d...
ORGANISM(S): Mus musculus 
2009-09-11 | E-GEOD-14549 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in the liver of 3-month old mice with a mutant Wrn protein treated with vitamin C compared to the liver of 3-month old untreated mice with a mutant Wrn protein.
Werner syndrome (WS) is a rare disorder characterized by the premature onset of a number of age-related diseases. The gene responsible for WS is believed to be involved in different aspects of transcription, replication, and/or DNA repair. We generated a mouse model with a deletion in the helicase d...
ORGANISM(S): Mus musculus 
2015-05-09 | E-GEOD-68688 | biostudies-arrayexpress
GenomicsGenome-wide map of HBO1 in cancer derived human cell line
We used ChIP-seq technology in order to map chromatin binding sites of the HBO1 MYST complex in the RKO cell line. We obtained a significant enrichment of the HBO1 signal right after TSS regions of genes and also In the proximal promoter region, with no signal on TSS. This enrichment also correlates...
ORGANISM(S): Homo sapiens 
2012-03-15 | E-GEOD-33007 | biostudies-arrayexpress
TranscriptomicsA critical role of microRNAs in human pulmonary arterial hypertension. miR-204: a novel therapeutic target (TaqMan qPCR)
Pulmonary arterial hypertension (PAH) is a vascular remodeling disease characterized by enhanced pulmonary artery smooth muscle cell (PASMC) proliferation and suppressed apoptosis. Downregulation of the BMPR2 gene along with activation of the transcription factor NFAT have been implicated in the mai...
ORGANISM(S): Homo sapiens 
2010-12-16 | E-GEOD-21281 | biostudies-arrayexpress
TranscriptomicsEffects of the JADE-HBO1 complex on gene expression
We find that 499 genes are up-regulated and 457 are down-regulated in response to over-expression of JADE1, while 397 genes are up-regulated and 385 are down-regulated after HBO1 knock-down. For each condition - HBO1 siRNA treatment or JADE1 over-expression - two biological replicates were analyzed ...
ORGANISM(S): Homo sapiens 
2012-03-15 | E-GEOD-33220 | biostudies-arrayexpress
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