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TranscriptomicsUBF Is An Epigenetic Factor Required For Ribosomal RNA Gene Activity And Preinitiation Complex Assembly But Not For Nucleolar Body Formation
Upstream Binding Factor (UBF) is a unique multi-HMGB-box protein first identified as a co-factor in RNA polymerase I (RPI/PolI) transcription. However, its poor DNA sequence selectivity and its ability to generate nucleosome-like nucleoprotein complexes suggest a more generalized role in chromatin s...
ORGANISM(S): Mus musculus 
2014-08-19 | E-GEOD-55450 | biostudies-arrayexpress
TranscriptomicsA critical role of microRNAs in human pulmonary arterial hypertension. miR-204: a novel therapeutic target
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2010-12-16 | E-GEOD-21284 | biostudies-arrayexpress
TranscriptomicsA critical role of microRNAs in human pulmonary arterial hypertension. miR-204: a novel therapeutic target (TaqMan qPCR)
Pulmonary arterial hypertension (PAH) is a vascular remodeling disease characterized by enhanced pulmonary artery smooth muscle cell (PASMC) proliferation and suppressed apoptosis. Downregulation of the BMPR2 gene along with activation of the transcription factor NFAT have been implicated in the mai...
ORGANISM(S): Homo sapiens 
2010-12-16 | E-GEOD-21281 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver from wild type and Wrn mutant animals with or without vitamin C treatment
Werner syndrome (WS) is a rare disorder characterized by the premature onset of a number of age-related diseases. The gene responsible for WS is believed to be involved in different aspects of transcription, replication, and/or DNA repair. We generated a mouse model with a deletion in the helicase d...
ORGANISM(S): Mus musculus 
2009-09-11 | E-GEOD-14549 | biostudies-arrayexpress
TranscriptomicsThe prognostic ease and difficulty of invasive breast carcinoma
Breast carcinoma (BC) have been extensively profiled by high-throughput technologies for over a decade, and broadly speaking, these studies can be grouped into those that seek to identify patient subtypes (studies of heterogeneity) or those that seek to identify gene signatures with prognostic or pr...
ORGANISM(S): Homo sapiens 
2014-10-08 | E-GEOD-58644 | biostudies-arrayexpress
TranscriptomicsMonitoring response and resistance to the novel arsenical darinaparsin in an AML patient
A patient diagnosed with AML with inversion of chromosome 3 inv(3)(q21q26.2) was treated with the organic arsenical darinaparsin on an experimental protocol. The patient underwent two treatment cycles. During the first, a stabilization of WBC counts was noted along with a marked improvement in subje...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-GEOD-43455 | biostudies-arrayexpress
TranscriptomicsA critical role of microRNAs in human pulmonary arterial hypertension. miR-204: a novel therapeutic target (gene expression)
Pulmonary arterial hypertension (PAH) is a vascular remodeling disease characterized by enhanced pulmonary artery smooth muscle cell (PASMC) proliferation and suppressed apoptosis. Downregulation of the BMPR2 gene along with activation of the transcription factor NFAT have been implicated in the mai...
ORGANISM(S): Homo sapiens 
2010-12-16 | E-GEOD-21280 | biostudies-arrayexpress
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