Backround&Aim: Dysbiosis of gut microbiota is closely related to the pathogenesis of osteoporosis (OP). This study aimed to identify probiotic candidates and gut-derived metabolites capable of ameliorating osteoporosis via modulation of bone metabolism. 

Methods: Ovariect...

The influence of amino acid restriction on obesity may be related to the gut microbiome, but the role and mechanism of lysine restriction (LR) on pediatric obesity is largely undefined. Here, we found plasma lysine levels were significantly higher in obese patients than healthy controls of childr...

The aim of this study was to establish a mouse model of Clostridioides difficile infection (CDI) and to investigate the effects of intervention with live Parabacteroides distasonis and its culture supernatant on the fecal bile acid pool using a targeted metabolomics approach. By...

Ulcerative colitis (UC) involves epithelial injury, gut microbial dysbiosis, disturbed microbial metabolism, and mucosal inflammation. This study evaluated the protective effect of Schisandra chinensis (SC) against dextran sulfate sodium (DSS)-induced UC and investigated the underlying microbiota...