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TranscriptomicsTranscription profiling by array of the paraxial mesoderm of zebrafish embryos - spatiotemporal analysis
Differentially expressed genes along the paraxial mesoderm of 12 somite stage zebrafish embryos are identified Tissue samples from 6 different spatial positions were dissected from wild-type (AB) embryos, RNA is amplified and hybridized to arrays
ORGANISM(S): Danio rerio 
2010-02-22 | E-GEOD-15796 | biostudies-arrayexpress
GenomicsBrg1 Modulates Enhancer Activation and Polycomb-mediated Repression in Mesoderm Differentiation [ChIP-exo]
We investigated the genome-wide occupancy changes in normal and Brg1-deleted mesoderm differentiation of mouse embryonic stem cells of chromatin regulators and histone modifications. ChIP exo for BRG1 in 2 conditions: Day4 THF (Control) and Day4 4OHT (Brg1-deleted). 1-2 replicates per condition.
ORGANISM(S): Mus musculus 
2015-03-01 | E-GEOD-63976 | biostudies-arrayexpress
TranscriptomicsIn vitro cultured H7 human embryonic stem cells (WiCell) and H7-derived downstream early mesoderm progenitors
Stem-cell differentiation to desired lineages requires navigating alternating developmental paths that often lead to unwanted cell types. Hence, comprehensive developmental roadmaps are crucial to channel stem-cell differentiation toward desired fates. To this end, here, we map bifurcating lineage c...
ORGANISM(S): Homo sapiens 
2016-08-02 | E-GEOD-85066 | biostudies-arrayexpress
TranscriptomicsExpression data of mESCs differentiated into Paraxial mesoderm
Stem cell-derived tissues have wide potential for modelling developmental and pathological processes as well as cell-based therapy. However, it has proven difficult to generate several key cell types in vitro, including skeletal muscle. In vertebrates, skeletal muscles derive during embryogenesis fr...
ORGANISM(S): Mus musculus 
2015-08-03 | E-GEOD-71348 | biostudies-arrayexpress
GenomicsParaxial mesoderm organoids model development of human somites
Paraxial mesoderm organoids model development of human somites
PRJNA799751 | ENA
TranscriptomicsThe Polycomb protein Pcgf2/Mel18 regulates mesoderm cell fate-specification of embryonic stem cells through multiple mechanisms
Polycomb complexes are essential regulators of stem cell identity, yet very little is known about their molecular mechanisms during cell differentiation. Pcgf proteins (Pcgf1/2/3/4/5/6) are core subunits of the Polycomb repressive complex 1 (PRC1). It has been recently proposed that specific Pcgf pr...
ORGANISM(S): Mus musculus 
2015-09-04 | E-GEOD-67868 | biostudies-arrayexpress
TranscriptomicsExpression data from undifferentiated human embryonic stem cells (hESC) and Day 3.5 mesodermal progenitor (CD326neg CD56+) population
Our understanding of how mesodermal tissue is formed, has been limited by the absence of specific and reliable markers of early mesoderm commitment. We report that mesoderm commitment from human embryonic stem cells (hESC) is initiated by Epithelial to Mesenchymal transition (EMT) as shown by gene e...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-21668 | biostudies-arrayexpress
Transcriptomicsexpression profiles in the chicken PSM differentiation at Stage 12HH chicken embryo
To examine global gene expression profile of chicken early paraxial mesoderm differentiation, we microdissected stage 12HH chicken PSM regions into 20 pieces (10 pieces both left-right PSM), including the tail bud, the PSM and somites. We create microarray series using these fragments. Duplicated 10...
ORGANISM(S): Gallus gallus 
2015-12-09 | E-GEOD-75798 | biostudies-arrayexpress
GenomicsExpression data of hPSCs differentiated into Paraxial mesoderm
Expression data of hPSCs differentiated into Paraxial mesoderm
PRJNA436908 | ENA
TranscriptomicsSingle cell gene expression of early E8.5 pioneer neural crest cells and paraxial mesoderm
Laser capture microdissection (LCM) was used to isolate cells from the principal critical micro-regions, whose development, differentiation and signaling interactions are responsible for the construction of the mammalian face. At E8.5, as migrating neural crest cells begin to exit the neural fold/ep...
ORGANISM(S): Mus musculus 
2014-03-18 | E-GEOD-55964 | biostudies-arrayexpress
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