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TranscriptomicsExpression data from mouse lung treated with saline or bleomycin
Lung fibrosis represents the final common pathway of a variety of lung injuries, and it is characterized, independently of etiology, by the expansion of the fibroblast/myofibroblast population and by the abnormal accumulation of extracellular matrix (ECM) replacing normal functional parenchyma. In g...
ORGANISM(S): Mus musculus 
2013-03-11 | E-GEOD-42301 | biostudies-arrayexpress
TranscriptomicsDevelopment of gene expression signatures for Mmp19 regulation of fibroblast phenotype in mouse lungs
We have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to distinguish Mmp19 regulation of fibroblast phenotype changes in mouse lungs. Pulmonary fibrosis was induced by bleomycin at 0.08 u in 50ul of saline. At 21st day the mice wer...
ORGANISM(S): Mus musculus 
2014-08-05 | E-GEOD-49643 | biostudies-arrayexpress
TranscriptomicsHuman alveolar epithelial cells (A549) exposed to cigarette smoke extract
Human alveolar epithelial cells were exposed to cigarette smoke extract (CSE) for 1, 3 and 5 weeks at 1%, 5% and 10%, and gene expression was evaluated by complete transcriptome microarrays. In this study we explored the effect of cigarette smoke on the gene expression profile. Human alveolar epith...
ORGANISM(S): Homo sapiens 
2016-02-16 | E-GEOD-77942 | biostudies-arrayexpress
TranscriptomicsGenome-wide mRNA expression profiles induced by infection with the pandemic and seasonal influenza A viruses in macrophages
Infection with pandemic A/H1N1 influenza virus induces high levels of circulating and lung pro-inflammatory cytokines and chemokines in experimental models and humans. These inflammatory mediators contribute to poor clinical outcomes of this infection. To compare the regulation of inflammatory respo...
ORGANISM(S): Homo sapiens 
2012-06-09 | E-GEOD-36012 | biostudies-arrayexpress
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