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TranscriptomicsExpression data in PD-L1 positive and PD-L1 negative human melanoma samples
Blocking the PD-1/PD-L1 immunosuppressive pathway has shown promise in the treatment of certain cancers including melanoma. This study investigates differences in the gene expression profiles of human melanomas that do or do not display the immunosuppressive protein PD-L1. Further understanding of g...
ORGANISM(S): Homo sapiens 
2015-05-01 | E-GEOD-65041 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse splenic dendritic cell subpopulations to characterize molecular differences among the cells.
To characterize differences between BALB/c splenic CD11cintB220+Gr1+ PDCs (plasmacytoid dendritic cells), CD11cintB220+CD49b+ IKDCs (interferon producing killer-dendritic cells), and CD11chighB220- cDCs (conventional dendritic cells), we performed gene expression profile analysis using Affymetrix ch...
ORGANISM(S): Mus musculus 
2007-11-01 | E-GEOD-3691 | biostudies-arrayexpress
TranscriptomicsExpression data in human renal cell carcinoma samples from patients who did or did not respond to anti-PD-1 (Nivolumab) immunotherapy
Pre-treatment tumor expression of PD-L1 has been shown to correlate with favorable clinical outcomes following PD-1 blocking therapies. However, the majority of patients with PD-L1+ tumors do not respond to treatment. With the goal of obtaining insights into the mechanisms underlying the response to...
ORGANISM(S): Homo sapiens 
2016-08-04 | E-GEOD-67501 | biostudies-arrayexpress
UnknownSurvival, Durable Response, and Long-Term Safety in Patients With Previously Treated Advanced Renal Cell Carcinoma Receiving Nivolumab.
Not available
S-EPMC4517051 | biostudies-literature
UnknownSurvival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab.
Not available
S-EPMC4811023 | biostudies-literature
UnknownOverall Survival and Long-Term Safety of Nivolumab (Anti-Programmed Death 1 Antibody, BMS-936558, ONO-4538) in Patients With Previously Treated Advanced Non-Small-Cell Lung Cancer.
Not available
S-EPMC4672027 | biostudies-literature
TranscriptomicsLoss of Foxp3-driven epigenetic modification leads to regulatory T cell insufficiency
Regulatory T cells (Tregs) are responsible for limiting autoimmunity and chronic inflammation. Foxp3 is a transcription factor that acts as a master regulator of Treg development and function. A serendipitous observation led to the realization that a well-characterized Foxp3gfp reporter mouse, whic...
ORGANISM(S): Mus musculus 
2012-12-07 | E-GEOD-35164 | biostudies-arrayexpress
GenomicsHomo sapiens
Expression data in PD-L1 positive and PD-L1 negative human melanoma samples
PRJNA272776 | ENA
TranscriptomicsTranscription profiling of mouse cell lines immune sensitive P0 and immune resistant P3 identifies a tumor immune evasion mechanism using P0 and P3 cell lines
The emergence of immune resistance variants during immunotherapy is poorly understood. We generated a highly immune resistant cell line (P3) from a susceptible cell line (P0) by subjecting it to 3 rounds of in vivo immune selection. Subsequently, microarray analysis of P0 and P3 was performed to i...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-2774 | biostudies-arrayexpress
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