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ProteomicsTIMELESS haploinsufficiency induces a PARG-dependency that is rescued by nucleoside supplementation, thus mimicking intrinsic PARG inhibitor sensitivity of ovarian cancer cells
A subset of cancer cells are intrinsically sensitive to inhibitors targeting PARG, the poly(ADP-ribose) glycohydrolase that degrades PAR chains. Sensitivity is accompanied by persistent DNA replication stress, and can be induced by inhibition of TIMELESS, a replisome accelerator. However, the nature...
ORGANISM(S): Homo sapiens (Human) 
2024-06-28 | PXD049682 | Pride
Parg inhibitor Dna replication Adp-ribosylation dda Ethcd Hgsoc Replication stress Lc-ms/ms 
UnknownSelective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Not available
S-EPMC6906431 | biostudies-literature
UnknownIntrinsic PARG inhibitor sensitivity is mimicked by TIMELESS haploinsufficiency and rescued by nucleoside supplementation.
Not available
S-EPMC11249981 | biostudies-literature
TranscriptomicsPaternal poly(ADP-ribose) metabolism modulates retention of inheritable sperm histones and early embryonic gene expression [Parg(110)_KO_sperm_MNase]
To achieve the extreme nuclear condensation necessary for sperm function, most histones are replaced with protamines during spermiogenesis in mammals. Mature sperm retain only a small fraction of nucleosomes, which are, in part, enriched on gene regulatory sequences, and recent findings suggest tha...
ORGANISM(S): Mus musculus 
2014-08-30 | E-GEOD-56281 | biostudies-arrayexpress
GenomicsPARG inhibitor sensitivity correlates with accumulation of single strand DNA gaps in preclinical models of ovarian cancer
PARG inhibitor sensitivity correlates with accumulation of single strand DNA gaps in preclinical models of ovarian cancer
PRJNA1126286 | ENA
UnknownReplication-associated base excision repair/single-strand break repair regulates PARG inhibitor response via the PRMT1/PRMT5/ATR axis.
Not available
S-EPMC12754786 | biostudies-literature
UnknownPARG inhibitor sensitivity correlates with accumulation of single-stranded DNA gaps in preclinical models of ovarian cancer.
Not available
S-EPMC11588084 | biostudies-literature
TranscriptomicsRNAi of human MCF7 cells knocked down for PARP-1 or PARGs
Poly(ADP-ribose) polymerase-1 (PARP-1) and poly(ADP-ribose) glycohydrolase (PARG) are enzymes that modify target proteins in the nucleus by the addition and removal, respectively, of ADP-ribose polymers. Although a role for PARP-1 in gene regulation has been well established, the role of PARG is le...
ORGANISM(S): Homo sapiens 
2009-10-30 | E-GEOD-12952 | biostudies-arrayexpress
TranscriptomicsPARG inhibitor sensitivity correlates with accumulation of single strand DNA gaps in preclinical models of ovarian cancer
Poly (ADP-ribose) glycohydrolase (PARG) is a dePARylating enzyme which promotes DNA repair by removal of poly (ADP-ribose) (PAR) from PARP1-parylated proteins. Loss or inhibition of PARG results in replication stress and sensitizes cancer cells to DNA damaging agents, suggesting that PARG inhibitors...
ORGANISM(S): Homo sapiens 
2024-10-31 | GSE270384 | GEO
UnknownIdentification of three critical acidic residues of poly(ADP-ribose) glycohydrolase involved in catalysis: determining the PARG catalytic domain.
Not available
S-EPMC1138956 | biostudies-literature
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