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ProteomicsProteomic analysis of Mycobacterial Biofilm Matrix and Development of Biofilm-binding Synthetic Nanobodies
Tissue-penetrating nanobodies as drug-delivery vehicles have shown efficacy in treating hard-to-reach and -treat diseases. The present study reports nanobodies with application potential in the treatment of tuberculosis (TB), especially the antibiotic tolerant biofilms that form in TB granulomas. Us...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) Mycobacterium marinum 
2023-03-30 | PXD033425 | Pride
Synthetic nanobody Mycobacterium Proteomics Sybody Surface proteome Biofilm Biotinylation 
TranscriptomicsProprotein Convertase Subtilisin/Kexin Type 7 (PCSK7) Is Essential for the Zebrafish Development and Bioavailability of Transforming Growth Factor β1a (TGFβ1a)
Proprotein convertase subtilisin/kexin (PCSK) enzymes convert proproteins into bioactive end products. Although other PCSK enzymes are known to be essential for biological processes ranging from cholesterol metabolism to host defense, the in vivo importance of the evolutionarily ancient PCSK7 has re...
ORGANISM(S): Danio rerio 
2014-01-02 | E-GEOD-42070 | biostudies-arrayexpress
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