This study uncovers host Metadherin (MTDH) as a pivotal regulator of systemic tumor progression, orchestrating liver metabolism and CD8⁺ T cell immunity. Tumor-derived extracellular vesicles prompt Kupffer cells to release TNFα and TGF-β, which, through MTDH-driven NF-κB signaling, suppress hepatic ...
ORGANISM(S): Mus musculus (Mouse)