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ProteomicsDistinguishing N-Terminal Methylation from Near-isobaric Modifications by Statistical Analysis of Mass Error Distributions of Fragment Ions
alpha-N-terminal methylation is an understudied post-translational modification with presumed functions involving protein-protein and/or protein-DNA interaction. The covalent addition of mono-, di-, trimethyl groups to free alpha-amino group has proven to be difficult to profile globally by mass spe...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-11-14 | MSV000096415 | MassIVE
ProteomicsExtracellular Matrix Proteome of Aging-Specific Fibrotic Niche Cells in Mouse Liver Tissue
The extracellular matrix (ECM) is a complex network comprising hundreds of proteins, serving not only a structural role in shaping multicellular organisms but also participating in signaling processes. Moreover, the ECM exhibits high tissue specificity and undergoes significant alterations with agin...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-13 | PXD060715 | Pride
Lc-ms/ms based proteomics Tandem mass tag (tmt) Senescence Extracellular matrix 
ProteomicsOne-STAGE Tip Method for TMT based Proteomic Analysis of Minimal Amount of Cells
LC-MS-based profiling of proteomes with isobaric tag labeling from low-quantity biological and clinical samples, including needle-core biopsies and laser capture microdissection, has been challenging due to limited amount and sample loss during preparation. To address this problem, we developed OnM ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-04-18 | MSV000091734 | MassIVE
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