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Dynamic environmental factors such as light, nutrients, salt, and temperature continuously affect chlorophototrophic microbial mats, requiring adaptive and acclimative responses to stabilize composition and function. Quantitative metabolomics analysis can provide insights into metabolite dynamics fo...
2024-02-23 | MTBLS187 | MetaboLights
There is an unmet need for chemical tools to explore the role of the Mediator complex in human pathologies ranging from cancer to cardiovascular disease. Here we determine that CCT251545 a WNT-pathway inhibitor discovered by cell-based screening is a potent and selective chemical probe for the Medi...
ORGANISM(S): Mus musculus 
Myeloid cell lines (K562 and HEL) were treated overnight with CHIR99021 or a vehicle control (DMSO). CHIR99021 treatment inhibits GSK3B within the destruction complex functioning in Wnt/beta-catenin signalling pathway, thereby preventing beta-catenin degradation and promoting its stabilization. Foll...
ORGANISM(S): Homo sapiens 
Analysis of dexamethasone treated substrates during 3 hr in HeLa cell. Total RNA obtained from HeLa cells with treatement of dexamethasone during 3hr. The up- or down-regulated transcripts were compare to control (DMSO) treated HeLa cell RNA extract. Significant transcripts were confirmed by replica...
ORGANISM(S): Homo sapiens 
This is a prepublication dataset that should change as updates are made to the underling genomes and annotations. Additional samples may be deposited and some samples may fail quality control. Please contact Haiwang Yang for details. The RNA-seq data set contains the transcr...
ORGANISM(S): Drosophila hawaiiensis 
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