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ProteomicshDPSC secretome restores cognitive function and synaptic plasticity by reducing ROS and alleviating neuroinflammation through M2 microglial polarization after ischemic stroke
Ischemic stroke triggers a cascade of oxidative stress, neuroinflammation, and synaptic dysfunction, leading to long-term cognitive and motor deficits. The human dental pulp stem cell (hDPSC) secretome, derived from neural crest-origin cells, has emerged as a promising cell-free therapeutic candidat...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2026-09-07 | PXD062727 | Pride
ProteomicsAnti-proteolytic regulation of KRAS by USP9X/NDRG3 in KRAS-driven cancer development
Cancers with activating mutations of KRAS show a high prevalence and poor prognosis but remain intractable, requiring innovative strategies to overcome the poor targetability of KRAS. Here, we report that KRAS expression was post-translationally up-regulated through the deubiquitination of KRAS prot...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD052379 | Pride
Kras protein deubiquitination  ndrg3  usp9x  pancreatic cancer 
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