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ProteomicsAntisense oligonucleotide-mediated inclusion of the TRA2β ultraconserved poison exon induces the expression of a lncRNA with anti-tumor effects
Dysregulated expression of oncogenic splicing factors (SFs) occurs in human tumors in part through alterations in splicing of poison exons (PE), highly conserved exons that trigger RNA degradation. TRA2β is one such SF that undergoes PE suppression in tumor cells. Therefore, manipulation of TRA2β-PE...
ORGANISM(S): Homo sapiens (Human) 
2024-12-20 | PXD042941 | Pride
Antisense oligonucleotide  poison exon  splicing factors  sr protein  tra2-beta  alternative rna splicing  breast cancer  splicing factor  triple negative breast cancer. rna-binding proteins  patient-derived xenograft  organoid  rna pulldown  mass spectrometry 
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