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UnknownProduction of α1,3-galactosyltransferase targeted pigs using transcription activator-like effector nuclease-mediated genome editing technology.
Recent developments in genome editing technology using meganucleases demonstrate an efficient method of producing gene edited pigs. In this study, we examined the effectiveness of the transcription activator-like effector nuclease (TALEN) system in generating specific mutations on the pig genome. Sp...
S-EPMC4808648 | biostudies-literature
UnknownCaliciBoost: Performance-driven evaluation of molecular representations for caco-2 permeability prediction.
Caco-2= permeability serves as a critical in vitro indicator for predicting the oral absorption of drug candidates= during early-stage drug discovery. To enhance the accuracy and= efficiency of computational predictions, we systematically investigated the impact of eight molecular feature= represent...
S-EPMC12752011 | biostudies-literature
UnknownTime-dependent mechanical-electrical coupled behavior in single crystal ZnO nanorods.
Nanoscale time-dependent mechanical-electrical coupled behavior of single crystal ZnO nanorods was systematically explored, which is essential for accessing the long-term reliability of the ZnO nanorod-based flexible devices. A series of compression creep tests combined with in-situ electrical measu...
S-EPMC4434914 | biostudies-literature
UnknownFactors related with colorectal and stomach cancer screening practice among disease-free lung cancer survivors in Korea.

Background

Lung cancer survivors are more likely to develop colorectal and stomach cancer than the general population. However, little is known about the current status of gastrointestinal cancer screening practices and related factors among lung cancer survivors.

Methods

We enrolled ...
S-EPMC5577681 | biostudies-literature
UnknownInduction of Apoptotic Cell Death by Oral Streptococci in Human Periodontal Ligament Cells.
Initiation and progression of oral infectious diseases are associated with streptococcal species. Bacterial infection induces inflammatory responses together with reactive oxygen species (ROS), often causing cell death and tissue damage in the host. In the present study, we investigated the effects ...
S-EPMC8551966 | biostudies-literature
UnknownThe Multi-Sites Trial on the Effects of Therapeutic Gardening on Mental Health and Well-Being.
Although many people affected by COVID-19 suffer from some form of psychological distress, access to proper treatment or psychosocial interventions has been limited. This study aimed to examine the feasibility and preliminary effects of a therapeutic gardening program conducted during the COVID-19 p...
S-EPMC9266122 | biostudies-literature
UnknownA Mobile Videoconference-Based Intervention on Stress Reduction and Resilience Enhancement in Employees: Randomized Controlled Trial.

Background

Videoconferencing-based treatments have shown great potential in increasing engagement and compliance by decreasing the barriers of time and distance. In general, employees tend to experience a lot of stress, but find it difficult to visit a clinic during office hours.

Objectiv...

S-EPMC6234345 | biostudies-literature
UnknownHigh Glucose Causes Human Cardiac Progenitor Cell Dysfunction by Promoting Mitochondrial Fission: Role of a GLUT1 Blocker.
Cardiovascular disease is the most common cause of death in diabetic patients. Hyperglycemia is the primary characteristic of diabetes and is associated with many complications. The role of hyperglycemia in the dysfunction of human cardiac progenitor cells that can regenerate damaged cardiac tissue ...
S-EPMC4930279 | biostudies-literature
UnknownA sexually transmitted sugar orchestrates reproductive responses to nutritional stress.
Seminal fluid is rich in sugars, but their role beyond supporting sperm motility is unknown. In this study, we found Drosophila melanogaster males transfer a substantial amount of a phospho-galactoside to females during mating, but only half as much when undernourished. This seminal substance, which...
S-EPMC11445483 | biostudies-literature
UnknownEnzyme-Aided Extraction of Fucoidan by AMG Augments the Functionality of EPCs through Regulation of the AKT/Rheb Signaling Pathway.
The purpose of the present study is to improve the endothelial progenitor cells (EPC) activation, proliferation, and angiogenesis using enzyme-aided extraction of fucoidan by amyloglucosidase (EAEF-AMG). Enzyme-aided extraction of fucoidan by AMG (EAEF-AMG) significantly increased EPC proliferation ...
S-EPMC6669526 | biostudies-literature
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