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ProteomicsIn vitro phosphorylation of trypsin-digested K562 cell lysate by TAM family kinases
K562 cell lysate was digested with trypsin, dephosphorylated with lambda phosphatase, and treated in an in vitro kinase reaction with Axl, Mer or Tyro3 kinase, alongside a control reaction for each that contained no kinase. Samples were phosphoenriched with the SMOAC approach (TiO2 and FeNTA) and an...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-08-29 | MSV000092784 | MassIVE
ProteomicsNovel Brutons Tyrosine Kinase (BTK) substrates for time-resolved luminescence assays
BTK substrate profile determined by treating digest KG-1 cell lysate with alkaline phosphatase followed by recombinant BTK. Samples were enriched with PolyMac phosphoenrichment kits prior to analysis. We have organized our uploaded files into three main folders: 1. BTK KALIP MS raw files: raw mass ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-22 | MSV000088429 | MassIVE
ProteomicsHigh-throughput identification of FLT3 wild-type and mutant kinase substrate preferences and application to design of sensitive in vitro kinase assay substrates
Abnormalities in the FLT3 signaling pathway play an integral role in AML disease relapse and drug resistance. Developing new and specific FLT3 tyrosine kinase inhibitors for use in combination to induction therapy is an important step to reduce disease relapse and achieve clinical remission. To deve...
ORGANISM(S): Homo sapiens (Human) 
2019-01-07 | PXD011478 | Pride
Kinase assay linked with phosphoproteomics Flt3 Acute myeloid leukemia Mass spectrometry Phosphoproteomics 
ProteomicsPRKACA_DnaJ overexpression in HEK293 cells Phosphoproteomics
Phosphoproteomics studies of PKA catalytic subunit or its DNAJB1-fused chimeric form overexpressed in HEK293 cells, under various conditions including inhibitors. Also includes in vitro rephosphorylation of cell lysates by each construct.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-01-15 | MSV000086707 | MassIVE
ProteomicsGFP-fused 53BP1 interacting proteins in HEK293-T cells with and without irradiation
Experiment: proteins immunoprecipitated with a GFP-fused 53BP1 fragment. Description: GFP-fused 53BP1 fragment was conditionally expressed (Tet-ON) in HEK293-T cells in duplicate. Cells were irradiated (6 Gy) or not, allowed to recover for 24 hours, cross linked with 0.05% paraformaldehyde, lysed wi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-01-03 | MSV000083293 | MassIVE
UnknownMultiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function.
Not available
S-EPMC6065313 | biostudies-literature
UnknownSmall-scale mutations are infrequent as mechanisms of resistance in post-PARP inhibitor tumour samples in high grade serous ovarian cancer.
Not available
S-EPMC10711013 | biostudies-literature
UnknownRare variant contribution to the heritability of coronary artery disease.
Not available
S-EPMC11464707 | biostudies-literature
UnknownTiming of whole genome duplication is associated with tumor-specific MHC-II depletion in serous ovarian cancer.
Not available
S-EPMC11258338 | biostudies-literature
UnknownPaclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms in ovarian cancer.
Not available
S-EPMC4015028 | biostudies-literature
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