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UnknownClarin-2 is essential for hearing by maintaining stereocilia integrity and function
Hearing relies on mechanically-gated ion channels present in the actin-rich stereocilia bundles at the apical surface of cochlear hair cells. Our knowledge of the mechanisms underlying the formation and maintenance of the sound-receptive structure is limited. Utilizing a large-scale forward genetic ...
S-SCDT-EMM-2019-10288 | biostudies-other
UnknownSociodemographic Differences in COVID-19 Pandemic Experiences Among Families in the United States.

Importance

Few population-based studies in the US collected individual-level data from families during the COVID-19 pandemic.

Objective

To examine differences in COVID-19 pandemic-related experiences in a large sociodemographically diverse sample of children and caregivers.

Design,...

S-EPMC10448300 | biostudies-literature
UnknownTwo phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.

Background

Bapineuzumab, a humanized anti-amyloid-beta monoclonal antibody, is in clinical development for the treatment of Alzheimer's disease.

Methods

We conducted two double-blind, randomized, placebo-controlled, phase 3 trials involving patients with mild-to-moderate Alzheimer's d...
S-EPMC4159618 | biostudies-literature
UnknownTwo Randomized Trials of Neutralizing Antibodies to Prevent HIV-1 Acquisition.

Background

Whether a broadly neutralizing antibody (bnAb) can be used to prevent human immunodeficiency virus type 1 (HIV-1) acquisition is unclear.

Methods

We enrolled at-risk cisgender men and transgender persons in the Americas and Europe in the HVTN 704/HPTN 085 trial and at-risk ...
S-EPMC8189692 | biostudies-literature
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