Parkinson's - OmicsDI

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Unknown (20664)
Genomics (776)
Transcriptomics (620)
Proteomics (328)
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Methylation profiling (17)
Genomic (11)
Other (7)
Clinical (3)
Multiomics (1)

Organisms

Homo sapiens (502)
Mus musculus (169)
Rattus norvegicus (37)
Drosophila melanogaster (21)
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Danio rerio (8)
Caenorhabditis elegans (7)
Streptomyces venezuelae (6)
Arabidopsis thaliana (6)
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cellular organisms (1)
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Cyanidioschyzon merolae (1)

Organisms

Homo sapiens (260)
Mus musculus (97)
Rattus norvegicus (20)
human gut metagenome (12)
Drosophila melanogaster (5)
mouse gut metagenome (5)
Caenorhabditis elegans (4)
feces metagenome (3)
human feces metagenome (3)
Mus (3)
Danio rerio (3)
gut metagenome (2)
Saccharomyces cerevisiae (2)
Mucuna pruriens var. utilis (1)
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Chlorocebus sabaeus (1)
Rattus rattus (1)
Eubacterium callanderi (1)
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synthetic RNA (1)
Lonchura striata (1)
human metagenome (1)
Bacteria (1)
human oral metagenome (1)
mouse metagenome (1)
unidentified (1)
Macaca fascicularis (1)

Repository

ENA (652)
biostudies-arrayexpress (417)
geo (311)
pride (228)
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EGA (38)
MetaboLights (27)
BioModels (22)
iProX (22)
ExpressionAtlas (12)
jPOST (12)
dbGaP (11)
PanoramaPublic (7)
GNPS (3)
EVA (2)
MetabolomicsWorkbench (2)
PAXDB (2)
PeptideAtlas (2)
PMR (2)
GPMDB (1)

Tissue

Prefrontal cortex (4)
Pylorus (1)
Synovial membrane of synovial joint (1)
Subthalamic nucleus (1)
Body of tongue (1)
Myometrium (1)
Dorsal root ganglion (1)
Set of muscles of vertebral column (1)
Pharyngeal mucosa (1)
Vena cava (1)
Mammalian vulva (1)
Urethra (1)
Medulla of organ (1)
Fundus of stomach (1)
Deltoid (1)
Ventral tegmental area (1)
Superior vestibular nucleus (1)
Substantia nigra pars compacta (1)
Pericardium (1)
Synovial joint (1)
Mucosa of oral region (1)
Mixed endometrium and ovary (1)
Umbilical vein endothelium (1)
Cerebellar vermis (1)
Cardia of stomach (1)
Inferior vagus X ganglion (1)
Adrenal cortex (1)
Peritoneum (1)
Nipple (1)
Trigeminal ganglion (1)

Disease

Parkinson's disease (205)
Normal (10)
Lewy body dementia (7)
Multiple system atrophy (5)
Progressive supranuclear palsy (2)
Essential tremor (1)
Corticobasal degeneration (1)
Alzheimers disease (1)
Adenocarcinoma (1)
Adenomyosis (1)
Uterine fibroid (1)
Neuromuscular pain (1)
Endometriosis (1)
Genetic frontotemporal degeneration with dementia (1)
Genetic frontotemporal degeneration with FUS inclusions (1)
Pathological aging (1)
Genetic frontotemporal degeneration with TDP inclusions (1)
Corticobasal degeneration (1)
Pick disease (1)
Amyotrophic lateral sclerosis (1)
Tangle predominant senile dementia (1)
Amyotrophic lateral sclerosis with dementia (1)
Parkinson's disease and Parkinson's disease dementia (1)
Genetic frontotemporal degeneration with ubiquitin inclusions (1)
Progressive supranuclear palsy (1)
Rheumatoid arthritis (1)
Control (1)
Prostate cancer (1)
Breast cancer (1)
None (1)

Technology Type

Mass Spectrometry (230)
Shotgun proteomics (112)
Bottom-up proteomics (46)
Affinity purification coupled with mass spectrometry proteomics (23)
SWATH MS (21)
Data-dependent acquisition (18)
Data-independent acquisition (17)
Mass spectrometry (16)
SRM/MRM (10)
Gel-based experiment (8)
Mass spectrometry assay (6)
Top-down proteomics (5)
Chemical cross-linking coupled with mass spectrometry proteomics (5)
NMR spectroscopy (3)
Illumina HiSeq 2000 (2)
NMR spectroscopy assay (2)
HDMSE (2)
ILLUMINA, Illumina HiSeq 2000 (1)
Illumina 1.2M, Illumina 610K Quad, Affymetrix 6.0 (1)
EI (1)
ESI (1)
Mass spectrometry imaging (1)
All-ion fragmentation (1)

Instrument Platform

Illumina NovaSeq 6000 (19)
NextSeq 500 (12)
Illumina HiSeq 2000 (11)
Illumina HiSeq 4000 (7)
Illumina NovaSeq X (6)
Illumina HiSeq 2500 (5)
Illumina Genome Analyzer IIx (3)
- (3)
Sequel (2)
NA (2)
Illumina MiSeq (2)
NextSeq 550 (2)
Illumina HiSeq 3000 (2)
Tapestri Platform (1)
Pacbio Revio (1)
-- (1)
Linux Bash Scripting (1)
NEBNext Ultra II Directional RNA Library Prep (1)
Qiagen RNeasy Mini Kit (1)
With L-glutamine supplemented with 10% fetal bovine serum (FBS) (Gibco) and 1% penicillin-streptomycin (10,000 units/mL penicillin and 10 mg/mL streptomycin) (Gibco). (1)
Sequel II (1)
Affymetrix miRNA 3.1 (1)
Not Applicable (1)
Not Applicablre (1)
Other (1)
Axon- GenePix4000B (1)
R (1)
TruSeq (Illumina, Novogene, Genomic Centre Cambridge, CB4 0FW, UK.) (1)
NanoDrop spectrophotometer and the Agilent 2100 Bioanalyzer (1)
Histopaque-1077,FACSAria Fusion Sorter,Flow Cytometer (1)

Publication Date

2025 (108)
2026 (107)
2024 (80)
2022 (71)
2023 (65)
2015 (64)
2010 (63)
2016 (62)
2014 (59)
2021 (58)
2013 (56)
2012 (56)
2011 (51)
2020 (47)
2018 (36)
2017 (29)
2019 (27)
2008 (26)
2009 (9)
2007 (8)
2004 (5)
2006 (4)
2005 (3)
2002 (1)

UNIPROT ID/AC

P37840 (8)
O60260 (3)
P09936 (3)
P20711 (2)
P21397 (2)
P0CG47 (2)
P07101 (2)
P13473 (2)
Q9BXM7 (1)
G4XXL9 (1)
Q99497 (1)
O95140 (1)
P14416 (1)
Q49A63 (1)
B3KTS5 (1)
P21796 (1)
Q5U5U6 (1)
O43464 (1)
Q53FS6 (1)
B4DR68 (1)
F5H897 (1)
Q12931 (1)
O60218 (1)
H6UYS5 (1)
L7RSM2 (1)
P49459 (1)
Q5VVX4 (1)
A0AVT1 (1)
P78417 (1)
P11142 (1)

ENSEMBL ID

ENSG00000170477 (2)
ENSG00000158828 (1)
ENSG00000154277 (1)
ENSG00000151552 (1)
ENSG00000116288 (1)
ENSG00000116688 (1)
ENSG00000142319 (1)
ENSG00000149295 (1)
ENSG00000213585 (1)
ENSG00000115317 (1)
ENSG00000093010 (1)
ENSG00000126602 (1)
ENSG00000180176 (1)
ENSG00000198074 (1)
ENSG00000111275 (1)
ENSG00000145335 (1)
ENSG00000112062 (1)
ENSG00000077721 (1)
ENSG00000132437 (1)
ENSG00000185345 (1)
ENSG00000033178 (1)
ENSG00000147251 (1)
ENSG00000247315 (1)

CHEBI ID

CHEBI:15422 (9)
CHEBI:16761 (8)
CHEBI:15741 (6)
CHEBI:16856 (6)
CHEBI:15765 (5)
CHEBI:18243 (4)
CHEBI:16474 (4)
CHEBI:16908 (4)
CHEBI:15846 (4)
CHEBI:18237 (4)
CHEBI:17895 (4)
CHEBI:18012 (4)
CHEBI:60425 (3)
CHEBI:26523 (3)
CHEBI:15356 (3)
CHEBI:16680 (3)
CHEBI:41941 (3)
CHEBI:17858 (3)
CHEBI:59560 (2)
CHEBI:60027 (2)
CHEBI:27978 (2)
CHEBI:545959 (2)
CHEBI:25212 (2)
CHEBI:15414 (2)
CHEBI:18421 (2)
CHEBI:29034 (2)
CHEBI:29033 (2)
CHEBI:16240 (2)
CHEBI:15377 (2)
CHEBI:15379 (2)

Metabolite Name

Creatine (6)
Taurine (6)
Lactate (5)
Creatinine (5)
2-Hydroxyisovalerate (4)
Acetoacetate (4)
3-Hydroxybutyrate (4)
2-Hydroxybutyrate (4)
Pyroglutamate (4)
Glycine (4)
Carnitine (4)
Glycerol (4)
Choline (4)
Hypoxanthine (4)
Pyruvate (4)
L-Alanine (4)
L-Serine (4)
Methanol (3)
Leucine (3)
GTP (3)
Succinate (3)
Aspartate (3)
Methionine (3)
Alanine (3)
D-Glucose (3)
Pantothenate (3)
N-Acetylglycine (3)
Betaine (3)
ATP (3)
Histamine (3)

First Public Date

2025 (93)
2026 (91)
2024 (87)
2014 (69)
2021 (56)
2022 (52)
2023 (50)
2020 (42)
2018 (22)
2017 (20)
2016 (19)
2013 (19)
2019 (18)
2015 (14)

Modelling Approach

Ordinary differential equation model (20)

Study status

Not yet recruiting (2)
Recruiting (1)

Lab affiliation

Paris-Saclay Institute of Neuroscience, Team Melki, CNRS, Gif-sur-Yvette, France (8)
Harvard Medical School Cell Biology Department (3)
Department of Neurology Institute for Cell Engineering Johns Hopkins University School of Medicine (2)
Instituto de Biomedicina de Sevilla (IBiS)-CSIC (2)
Rush University Medical Center (2)
Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana 47907, United States (2)
Department of Oncology-Pathology, Karolinska Institutet and Science for Life Laboratory, Stockholm, Sweden (2)
Department of Biochemistry and Molecular Biology, Protein Research group, University of Southern Denmark, Odense, Denmark (2)
Structural Biology & Developmental Neurobiology Director, St. Jude Proteomics Facility St. Jude Children's Research Hospital 262 Danny Thomas Place, Memphis, TN 38105 (2)
Université de Montréal (2)
Max Planck Institute of Biochemistry (2)
Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen N, Denmark (1)
ADLQ (1)
Northwestern University Feinberg School of Medicine (1)
MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, United Kingdom DD1 5EH, UK (1)
University of Toronto | U of T · Tanz Centre for Research in Neurodegenerative Diseases (1)
The Walter and Eliza Hall Institute of Medical Research Professor of Medical Biology, University of Melbourne, Australia (1)
Nuffield Department of Clinical Neurosciences, Oxford University, United Kingdom (1)
Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA (1)
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, United States (1)
Dept of Neurology University Hospital RWTH Aachen Pauwelsstrasse 30 52074 Aachen Germany (1)
Emory University School of Medicine Biochemistry Department (1)
Biomedical Research Institute, Foundation for Research and Technology-Hellas, Ioannina, Greece. (1)
Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA (1)
Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Children's Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA. (1)
Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa (1)
Department of Biochemistry and Chemistry, La Trobe University, Melbourne, VIC 3086 Australia (1)
Department of Biology, University of Konstanz, 78457 Konstanz, Germany (1)
Forschungsinstitut für Frauengesundheit Universitäts- Frauenklinik Universitätsklinikum Tübingen Germany (1)
Istituto Italiano di Tecnologia Via Morego 30, 16163 Genova Italy (1)

Keyword

Diabete Mellitus (1)
Sickle Cell Disease (1)
Sjogren’s Syndrome (1)

IsPrivate

False (22)

Model Flag

Non Kinetic (3)

Classification

bacteria (2)

Modification

Not available (1)

Study type

Transcription profiling by array (235)
RNA-seq of coding RNA (65)
ChIP-seq (22)
Comparative genomic hybridization by array (13)
RNA-seq of non coding RNA (8)
High-throughput sequencing (7)
Transcription profiling by tiling array (7)
Proteomic profiling by array (7)
RNA-seq of coding RNA from single cells (7)
Other (6)
ChIP-chip by array (5)
Methylation profiling by high throughput sequencing (5)
RNA-seq of total RNA (5)
Unknown experiment type (4)
Genotyping by array (4)
MicroRNA profiling by array (3)
DNA-seq (3)
Transcription profiling by SAGE (2)
Cell line - One-color microarray (2)
Cell line - High-throughput sequencing (2)
Observational (2)
ChIP-chip by tiling array (1)
RNAi profiling by array (1)
Bisulfite-seq (1)
ScATAC-seq (1)
Genotyping by high throughput sequencing (1)
Interventional (1)

Release Date

2025 (2558)
2022 (2527)
2023 (2396)
2024 (2220)
2021 (2198)
2020 (1740)
2019 (1260)
2018 (1092)
2017 (952)
2016 (827)
2015 (697)
2014 (638)
2013 (389)
2012 (339)
2026 (315)
2011 (281)
2010 (211)
2009 (124)
2008 (113)
2007 (68)
2006 (37)
2004 (28)
2005 (23)
2003 (13)
2002 (12)
2000 (7)
2001 (5)
1999 (3)
1998 (3)

Location

New Zealand (1)
Australia (1)
United States (1)

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Metabolomics of sebum reveals lipid dysregulation in Parkinson's disease

Parkinson's disease (PD) is a progressive neurodegenerative disorder, which is characterised by degeneration of distinct neuronal populations, including dopaminergic neurons of the substantia nigra. Here, we use a metabolomics profiling approach to identify changes to lipids in PD observed in sebum,...

2020-12-21 | MTBLS2266 | MetaboLights

Metabolic Profiling of CSF from People Suffering from Sporadic and LRRK2 Parkinson's Disease: A Pilot Study

CSF from unique groups of Parkinson's disease (PD) patients was biochemically profiled to identify previously unreported metabolic pathways linked to PD pathogenesis, and novel biochemical biomarkers of the disease were characterized. Utilizing both 1H NMR and DI-LC-MS/MS we quantitatively profiled ...

2022-09-02 | MTBLS863 | MetaboLights

Integrative Metabolomics-GWAS Mendelian Randomization Reveals Causal Metabolic and Inflammatory Drivers of Parkinson's Disease

Parkinson's disease (PD) is the second most common neurodegenerative disorder, characterized by a complex pathogenesis involving the interplay of multiple molecular and cellular pathways. In recent years, metabolic dysregulation and neuroinflammation have been recognized as key contributors to PD...

2025-11-05 | MTBLS13269 | MetaboLights

Aerobic exercise and gut flora: a key link to improved cognitive impairment in mice with Parkinson's disease

Parkinson's disease (PD) is a common neurodegenerative disorder. It is marked by motor dysfunction and cognitive decline. In recent years, scientific studies have found that PD's pathogenesis may be tied to an imbalance in the gut microbiota. This offers new perspectives for PD treatment. Modulat...

2025-10-12 | MTBLS13123 | MetaboLights

Targeted Bile Acid Metabolomic Profiling of Plasma Samples in Patients with Parkinson's Disease

Targeted LC-MS metabolomic profiling was performed on plasma samples from a validation cohort comprising 20 patients with Parkinson's disease and 20 healthy controls. The study aimed to verify altered circulating bile acid levels identified in the discovery cohort, assess correlations between bil...

2026-09-03 | MTBLS15429 | MetaboLights

Transgenic Parkinson's Mice Following Immunotherapy

Not available

ORGANISM(S): Mus musculus

ST001281 | MetabolomicsWorkbench

Alterations of fecal microbiota and plasma metabolome in patients with Parkinson's disease with rapid eye movement sleep disorder

Objectives: Patients with Parkinson's disease (PD) with probable Rapid eye movement sleep Behavior Disorder (RBD) (PD-RBD), a specific subtype of PD, is characterized by the presence of more severe motor and non-motor symptoms. This study aimed to elucidate the characteristics and interactions of...

2025-05-07 | MTBLS11094 | MetaboLights

Sex and subtype differences shape the blood metabolome profiles in Parkinson's disease.

Rationale: Sex and type of Parkinson's disease (PD) significantly influence onset age, clinical manifestations, treatment response, disease progression and life expectancy. However, the selective influence of idiopathic and familial forms of PD in disrupting blood metabolome profiles across gende...

2025-09-03 | MTBLS11187 | MetaboLights

Lactobacillus reuteri DSM17938 and its supernatant ameliorate parkinson's disease: insights from multi-omics and network pharmacology

The mechanisms by which probiotics ameliorate neurodegenerative diseases have garnered significant scientific interest, yet elucidating their underlying pathways remains challenging. In this study, we establish an integrated multi-omics and network pharmacology strategy to unravel the prote...

2025-10-18 | MTBLS13169 | MetaboLights

Transcriptional analysis of multiple brain regions in Parkinson's disease

Transcriptional analysis of multiple brain regions in Parkinson's disease supports the involvement of specific protein processing, energy metabolism, and signaling pathways, and suggests novel disease mechanisms. This SuperSeries is composed of the following subset Series: GSE20168: Transcriptional...

ORGANISM(S): Homo sapiens

2010-03-23 | E-GEOD-20295 | biostudies-arrayexpress

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