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TranscriptomicsA microRNA microarray analysis of C.elegans Parkinsons disease models
MicroRNAs (miRNAs) play an important role in human brain development and maintenance. To search for miRNAs potentially involved with molecular mechanisms in the pathogenesis of Parkinsons disease (PD), we utilized miRNA microarrays to identify expression changes of 115 annotated Caenorhabditis elega...
ORGANISM(S): Caenorhabditis elegans 
2010-06-20 | E-GEOD-14899 | biostudies-arrayexpress
MetabolomicsMetabolomics of sebum reveals lipid dysregulation in Parkinson's disease
Parkinson's disease (PD) is a progressive neurodegenerative disorder, which is characterised by degeneration of distinct neuronal populations, including dopaminergic neurons of the substantia nigra. Here, we use a metabolomics profiling approach to identify changes to lipids in PD observed in sebum,...
2020-12-21 | MTBLS2266 | MetaboLights
MetabolomicsMetabolomic Changes in Idiopathic and GBA1 Parkinson’s Disease

Background Variants in the β-glucocerebrosidase (GBA1) gene are the commonest genetic risk factor for Parkinson Disease (PD). Here, we use mass spectrometry based metabolomics to analyse serum and sebum samples from 50 genotyped participants and find differences in lipid and sugar reg...

2025-09-18 | MTBLS10743 | MetaboLights
MetabolomicsClassification of Parkinson’s Disease and Delineating Progression Markers from the Sebum Volatilome

Parkinson's Disease (PD) has been associated with a distinct odour, which emanates from the skin and is strongest in sebum-rich areas. In this study, sebum was sampled from participants using cotton gauze and the volatile components emanating from these swabs were analysed directly with thermal d...

2025-07-15 | MTBLS11712 | MetaboLights
MetabolomicsIntegrative Metabolomics-GWAS Mendelian Randomization Reveals Causal Metabolic and Inflammatory Drivers of Parkinson's Disease

Parkinson's disease (PD) is the second most common neurodegenerative disorder, characterized by a complex pathogenesis involving the interplay of multiple molecular and cellular pathways. In recent years, metabolic dysregulation and neuroinflammation have been recognized as key contributors to PD...

2025-11-05 | MTBLS13269 | MetaboLights
ProteomicsThe Vermiform Appendix Contributes to the Development of Parkinsons Disease
Top Down Proteomics Data associated with detection of synuclein proteoforms in The Vermiform Appendix Contributes to the Development of Parkinsons Disease
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-05-09 | MSV000082353 | MassIVE
MetabolomicsAlterations of fecal microbiota and plasma metabolome in patients with Parkinson's disease with rapid eye movement sleep disorder

Objectives: Patients with Parkinson's disease (PD) with probable Rapid eye movement sleep Behavior Disorder (RBD) (PD-RBD), a specific subtype of PD, is characterized by the presence of more severe motor and non-motor symptoms. This study aimed to elucidate the characteristics and interactions of...

2025-05-07 | MTBLS11094 | MetaboLights
TranscriptomicsDerivation, characterization, and neuronal differentitation of integration-free induced pluripotent stem cell lines from Parkinsons disease patients carrying SNCA, LRRK2, PARK2, and GBA mutations
Analysis of whole genome expression in control and patients with Parkinsons disease iPSC lines. The hypothesis tested in present study was that deficient GBA, SNCA, LRRK2 and PARKIN expression can be used for disease modeling by their affects on multiple pathways. These results provide information o...
ORGANISM(S): Homo sapiens 
2016-02-23 | E-GEOD-78152 | biostudies-arrayexpress
ProteomicsDiscovery and validation of biomarkers for Parkinson’s disease from human cerebrospinal fluid using mass spectrometry-based proteomics analysis
Proteomic biomarkers for Parkinsons disease (PD) are critical for identifying new targets for disease modifying therapies and expanding our understanding of the disease pathophysiology.
ORGANISM(S): Homo sapiens (Human) 
2025-09-01 | PXD055996 | Pride
Proteomics Parkinsons disease Csf Biomarker 
MetabolomicsAerobic exercise and gut flora: a key link to improved cognitive impairment in mice with Parkinson's disease

Parkinson's disease (PD) is a common neurodegenerative disorder. It is marked by motor dysfunction and cognitive decline. In recent years, scientific studies have found that PD's pathogenesis may be tied to an imbalance in the gut microbiota. This offers new perspectives for PD treatment. Modulat...

2025-10-12 | MTBLS13123 | MetaboLights
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