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TranscriptomicsExpression data from control and mutant TIFIACaMKCreERT2
We inhibited RNA polymerase I by genetic ablation of the basal transcription factor TIF-IA in adult hippocampal neurons. Nucleolar stress resulted in progressive neurodegeneration, although with a differential vulnerability within the CA1, CA3 and dentate gyrus. Here, we investigate the consequences...
ORGANISM(S): Mus musculus 
2013-09-28 | E-GEOD-51240 | biostudies-arrayexpress
TranscriptomicsExpression data from 9 and 13 weeks old TIFIAD1Cre mice
We have investigated the p53-dependent stress response in medium spiny neurons (MSNs) that degenerate in Huntington’s disease. To induce p53 signaling cascade, we have genetically inactivated by the Cre/loxP system the essential RNA polymerase I (Pol I) transcription factor TIF-IA, leading to stabil...
ORGANISM(S): Mus musculus 
2011-06-01 | E-GEOD-29647 | biostudies-arrayexpress
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