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TranscriptomicsSensitivity-resistance to the atypical retinoid ST1926 in NB4 acute myeloid leukemia cells
The two cell lines NB4 and NB4.437r, respectively sensitive and resistant to the cytotoxic action of the atypical retinoid ST1926 and CD437 were used to unveil the mechanism of action of these drugs.We compared their transcriptional profiles in conditions of exponential growth in basal medium by mic...
ORGANISM(S): Homo sapiens 
2013-01-08 | E-MEXP-3752 | biostudies-arrayexpress
TranscriptomicsLapatinib and retinoic acid combination treatment of SKBR3 breast cancer cells
SKBR3 cells, which bear both an HER2 and a RARA gene amplification, were treated for 12 or 48 hours with 100 nM retinoic acid, 100 nM lapatinib or the combination.The two drugs synergize and induce massive apoptosis. The aim is to find the molecular mechanism(s) of this synergism. Gene expression pr...
ORGANISM(S): Homo sapiens 
2011-10-06 | E-MEXP-3192 | biostudies-arrayexpress
TranscriptomicsAll trans-retinoic acid (ATRA) effect on triple negative (TNBC) and luminal (LumA/LumB) primary breast tumors
We performed whole genome gene expression microarrays on short-term cultures of mammary tumors deriving from diagnostic Tru-cut procedures of 16 patients in order to evaluate transcriptional response to the retinoid. Tissue slices were challenged with vehicle (DMSO) or ATRA 0.1åµm for 48 hours. The ...
ORGANISM(S): Homo sapiens 
2015-03-31 | E-MTAB-3313 | biostudies-arrayexpress
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