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ProteomicsUncoupling of PARP1 Trapping and Inhibition Using Selective PARP1 Degradation
PARP1 inhibitors (PARPi) are known to kill tumor cells via two mechanisms (i.e., PARP1 catalytic inhibition vs. PARP1 trapping). The relative contribution of these two pathways in mediating the cytotoxicity of PARPi, however, is incompletely understood. Here we designed a series of small molecule PA...
ORGANISM(S): Homo sapiens (Human) 
2019-08-01 | PXD014836 | Pride
Hela cell Irucaparib-tp3 Parp1 degradation 
ProteomicsUncoupling of PARP1 Trapping and Inhibition Using Selective PARP1 Degradation
PARP1 inhibitors (PARPi) are known to kill tumor cells via two mechanisms (i.e., PARP1 catalytic inhibition vs. PARP1 trapping). The relative contribution of these two pathways in mediating the cytotoxicity of PARPi, however, is incompletely understood. Here we designed a series of small molecule PA...
ORGANISM(S): Homo sapiens (Human) 
2019-08-01 | PXD014837 | Pride
Bt-549 cell Vrucaparib-tp4 Irucaparib-tp3 Parp1 degradation 
ProteomicsUncoupling of PARP1 Trapping and Inhibition Using Selective PARP1 Degradation
PARP1 inhibitors (PARPi) are known to kill tumor cells via two mechanisms (i.e., PARP1 catalytic inhibition vs. PARP1 trapping). The relative contribution of these two pathways in mediating the cytotoxicity of PARPi, however, is incompletely understood. Here we designed a series of small molecule PA...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-08-01 | PXD014838 | Pride
Primary neonatal rat cardiomyocyte Irucaparib Irucaparib-tp5 Parp1 degradation 
ProteomicsUncoupling of PARP1 Trapping and Inhibition Using Selective PARP1 Degradation
PARP1 inhibitors (PARPi) are known to kill tumor cells via two mechanisms (i.e., PARP1 catalytic inhibition vs. PARP1 trapping). The relative contribution of these two pathways in mediating the cytotoxicity of PARPi, however, is incompletely understood. Here we designed a series of small molecule PA...
ORGANISM(S): Homo sapiens (Human) 
2019-08-01 | PXD014840 | Pride
Rucaparib Parylated proteome Hela cell Irucaparib-tp3 Irucaparib 
ProteomicsUncoupling of PARP1 Trapping and Inhibition Using Selective PARP1 Degradation
PARP1 inhibitors (PARPi) are known to kill tumor cells via two mechanisms (i.e., PARP1 catalytic inhibition vs. PARP1 trapping). The relative contribution of these two pathways in mediating the cytotoxicity of PARPi, however, is incompletely understood. Here we designed a series of small molecule PA...
ORGANISM(S): Homo sapiens (Human) 
2019-08-01 | PXD014839 | Pride
Rucaparib Hela cell Irucaparib Parp trapping Chromatin 
ProteomicsNucleophagy removes cytotoxic trapped PARP1
Poly (ADP-ribose) polymerase inhibitors (PARPi) induce cytotoxicity in homologous recombination repair (HRR)-deficient cancers by causing PARP1 to become trapped on chromatin, resulting in irreparable replication-associated DNA damage. Cancer cells commonly develop resistance to PARPi, with a recent...
ORGANISM(S): Homo sapiens (Human) 
2026-04-15 | PXD071389 | Pride
Hdx-ms 
UnknownUncoupling of PARP1 trapping and inhibition using selective PARP1 degradation.
Not available
S-EPMC6864272 | biostudies-literature
GenomicsSelective nucleophagy removes cytotoxic trapped PARP1
Selective nucleophagy removes cytotoxic trapped PARP1
PRJNA1162042 | ENA
UnknownUSP1 promotes cholangiocarcinoma progression by deubiquitinating PARP1 to prevent its proteasomal degradation.
Not available
S-EPMC10567853 | biostudies-literature
TranscriptomicsSelective nucleophagy removes cytotoxic trapped PARP1
Poly (ADP-ribose) polymerase inhibitors (PARPi) induce cytotoxicity in homologous recombination deficient cancers by causing PARP1 to become trapped on chromatin, resulting in irreparable replication-associated DNA damage. Cancer cells commonly develop resistance to PARPi, with a recently proposed m...
ORGANISM(S): Homo sapiens 
2026-03-23 | GSE277366 | GEO
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