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Poly(ADP-ribose) Polymerase-13 (PARP13/ZAP/ZC3HAV1) is an antiviral factor, active against specific RNA viruses such as MLV, SINV and HIV. During infection PARP13 binds viral RNA via its 4 CCCH-type zinc finger domains and targets it for degradation by recruiting cellular mRNA decay factors such as ...
ORGANISM(S): Homo sapiens 
2014-11-13 | GSE56667 | GEO
Transcriptome Regulation by PARP13 in Basal and Antiviral States in Human Cells (eCLIP)
The RNA-binding protein PARP13 is a primary factor in the innate antiviral response. PARP13 can suppress translation and drive decay of bound viral and host RNA. PARP13 interacts with many proteins encoded by interferon-stimulated genes (ISG) to perform its antiviral activities, such as activation o...
ORGANISM(S): Homo sapiens 
2023-09-11 | GSE215250 | GEO
Transcriptome Regulation by PARP13 in Basal and Antiviral States in Human Cells (RNA-Seq)
The RNA-binding protein PARP13 is a primary factor in the innate antiviral response. PARP13 can suppress translation and drive decay of bound viral and host RNA. PARP13 interacts with many proteins encoded by interferon-stimulated genes (ISG) to perform its antiviral activities, such as activation o...
ORGANISM(S): Homo sapiens 
2025-10-10 | GSE215249 | GEO
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