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ProteomicsDELTEX2 C-terminal domain recruits ADP-ribosylated DNA damage repair proteins for ubiquitination.
Crosstalk between ubiquitination and ADP-ribosylation regulates spatio-temporal recruitment of key players during DNA damage repair (DDR). The Deltex family of ubiquitin ligases (DTX1–4 and DTX3L), are characterized by a RING domain followed by a C-terminal domain (DTC) of unknown function; four Del...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD017807 | Pride
Par-binding domain Deltex c-terminal domain Parylation-dependent ubiquitination Dtx Dna damage 
UnknownPARG inhibition suppresses breast cancer progression and potentiates immunoresponse through MTDH degradation mediated by E3 ligase ITCH-dependent ubiquitination.
Not available
S-EPMC12714780 | biostudies-literature
UnknownCBFβ Regulates RUNX3 ADP-Ribosylation to Mediate Homologous Recombination Repair.
Not available
S-EPMC12131651 | biostudies-literature
ProteomicsPARylation of UBC13 and PDI proteins
NH2OH was used to remove PAR from the PARylated proteins. This treatment left on the PARylated residues a hydroxamic acid derivative, which has a signature mass increase of +15.0109 Da and could be distinguished by mass spectrometry.
ORGANISM(S): Arabidopsis Thaliana (ncbitaxon:3702) 
2021-07-23 | MSV000087876 | MassIVE
UnknownPARP1-MGMT complex underpins pathway crosstalk in O6-methylguanine repair.
Not available
S-EPMC9563463 | biostudies-literature
UnknownThe PARP1-Siah1 Axis Controls HIV-1 Transcription and Expression of Siah1 Substrates.
Not available
S-EPMC6223328 | biostudies-literature
UnknownAllosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.
Not available
S-EPMC4289021 | biostudies-literature
ProteomicsPARP5A and RNF146 phase separation restrains RIPK1-dependent necroptosis
Phase separation is a vital mechanism that mediates the formation of biomolecular condensates and their functions. Necroptosis is a lytic form of programmed cell death mediated by RIPK1, RIPK3 and MLKL downstream of TNFR1 and other receptors and has been implicated in mediating many human diseases. ...
ORGANISM(S): Mus Musculus 
2023-11-14 | PXD046931 |
UnknownMORC2 regulates DNA damage response through a PARP1-dependent pathway.
Not available
S-EPMC6895267 | biostudies-literature
UnknownVGLL3 modulates chemosensitivity through promoting DNA double-strand break repair.
Not available
S-EPMC11463272 | biostudies-literature
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