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MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
GenomicsMapping meiotic crossovers in Arabidopsis using low-coverage whole-genome sequencing
Whole-genome DNA libraries were prepared from a population of just under 100 Col/Ler F1 backcrossed to Col. Low-coverage whole-genome sequencing was used to map meiotic crossovers in this population following the protocol described in Rowan et al., 2015, doi: 10.1534/g3.114.016501.
ORGANISM(S): Arabidopsis thaliana 
2015-10-15 | E-MTAB-3926 | biostudies-arrayexpress
GenomicsChIP-Seq reveals regulation of the heterochromatic mark, H3K9me3, in NAc following repeated cocaine administration
Repeated administration of the psychostimulant cocaine has been shown to produce persistent alterations in genome-wide transcriptional regulatory networks, chromatin remodeling activity and, ultimately, gene expression profiles in the brain’s reward circuitry. Virtually all previous investigations h...
ORGANISM(S): Mus musculus 
2011-01-18 | E-GEOD-24850 | biostudies-arrayexpress
ProteomicsRNF5 interactome
Cells expressing Flag-tagged RNF5 or empty vector were incubated with the proteasome inhibitor MG132 to block protein degradation. Cell lysates were then prepared and immunoprecipitationed with anti-Flag antibody were performed, and eluates were digested with trypsin and analyzed on a Q Exactive.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-11-25 | MSV000083160 | MassIVE
TranscriptomicsProfiling oxidative stress in Saccharomyces cerevisiae by oxidation of transcription factor Swi6p
Cell cycle sensing of oxidative stress in Saccharomyces cerevisiae by oxidation of a specific cysteine residue in the transcription factor Swi6p. Yeast cells begin to bud and enter S phase when growth conditions are favourable during G1 phase. When subjected to oxidative stress, cells arrest at G1 d...
ORGANISM(S): Saccharomyces cerevisiae 
2011-01-31 | E-GEOD-18334 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of epididymal adipose tissue from wild-type and Maf1 knockout mice
Purpose: To profile the effect of the Maf1 knockout on RNA polymerase II and RNA polymerase III transcriptomes in white adipose tissue Methods: Epididymal adipose tissue was harvested from overnight fasted 22-24 week old male mice that had been fed ad libitum on a chow diet. Total RNA was prepared f...
ORGANISM(S): Mus musculus 
2015-05-04 | E-GEOD-65976 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila cell lines S3, Kc and S3
Background: We would like to use Drosophila cell lines to investigate the transcriptional responses to Nitric Oxide donors and inhibitors. As a pilot to this we would like to compare the transcriptional profile of 3 cell lines we are using in our lab (S3, Kc and S3). This study is being done in para...
ORGANISM(S): Drosophila melanogaster 
2004-05-07 | E-FLYC-4 | biostudies-arrayexpress
TranscriptomicsRNAseq of 6 medulloblastoma cell lines
Medulloblastoma is subdivided into different subgroups: WNt, SHH, Group 3 and Group 4. Since these subgroups are associated with different OS and metastasis rates it is crucial to understand them better. Six medulloblastoma cell lines, DAOY, ONS-76, D458, HD-MB03, CHLA-01-MED, CHLA-01R-MED, have bee...
ORGANISM(S): Homo sapiens 
2022-03-02 | E-MTAB-9823 | biostudies-arrayexpress
TranscriptomicsGenomic analysis of diffuse pediatric low-grade gliomas identifies recurrent, oncogenic MYBL1-truncating rearrangements
Pediatric low-grade gliomas (PLGGs) are among the most common solid tumors in children but apart from BRAF mutations or duplications in specific subclasses, few genetic driver events are known. Diffuse PLGGs comprise a set of uncommon subtypes that exhibit invasive growth and are therefore especiall...
ORGANISM(S): Homo sapiens 
2013-04-23 | E-GEOD-45843 | biostudies-arrayexpress
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