Pastor William A WA

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Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells

5hmC and TET proteins have been implicated in stem cell biology and cancer, but information on the genome-wide distribution of 5hmC is limited. Here we describe two novel and specific approaches to profile the genomic localisation of 5hmC. The first approach, termed GLIB (GLucosylation, perIodate o...

ORGANISM(S): Mus musculus

2011-04-21 | E-GEOD-28682 | biostudies-arrayexpress

Mutant p53 Disrupts Mammary Acinar Morphogenesis via the Mevalonate Pathway

p53 is a frequent target for mutation in human tumors and previous studies have revealed that these missense mutant proteins can actively contribute to tumorigenesis. To elucidate how mutant p53 might contribute to mammary carcinogenesis we employed a three-dimensional (3D) culture model. In 3D cul...

ORGANISM(S): Homo sapiens

2012-02-13 | E-GEOD-31812 | biostudies-arrayexpress

p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression.

Not available

S-EPMC6483089 | biostudies-literature

Baseline Features and Reasons for Nonparticipation in the Colonoscopy Versus Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM) Study, a Colorectal Cancer Screening Trial.

Not available

S-EPMC10336619 | biostudies-literature

Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.

Not available

S-EPMC12535838 | biostudies-literature

Global age-sex-specific all-cause mortality and life expectancy estimates for 204 countries and territories and 660 subnational locations, 1950-2023: a demographic analysis for the Global Burden of Disease Study 2023.