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TranscriptomicsTranscription profiling of Drosophila developmental time series
Michelle N. Arbeitman, Eileen E. M. Furlong, Farhad Imam, Eric Johnson, Brian H. Null, Bruce S. Baker, Mark A. Krasnow, Matthew P. Scott, Ronald W. Davis and Kevin P. White. Gene Expression During the Life Cycle of Drosophila melanogaster, Science, 297: 2270-2275, 2002. This work can be accessed fro...
ORGANISM(S): Drosophila melanogaster 
2004-11-06 | E-FLYC-6 | biostudies-arrayexpress
TranscriptomicsGenome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells
5hmC and TET proteins have been implicated in stem cell biology and cancer, but information on the genome-wide distribution of 5hmC is limited. Here we describe two novel and specific approaches to profile the genomic localisation of 5hmC. The first approach, termed GLIB (GLucosylation, perIodate o...
ORGANISM(S): Mus musculus 
2011-04-21 | E-GEOD-28682 | biostudies-arrayexpress
GenomicsMORC1 represses transposable elements in the mouse male germ line
The Microrchidia (Morc) family of GHKL ATPases are present in a wide variety of prokaryotic and eukaryotic organisms but are of largely unknown function. Genetic screens in Arabidopsis thaliana have identified Morc genes as important repressors of transposons and other DNA methylated and silent gene...
ORGANISM(S): Mus musculus 
2014-12-12 | E-GEOD-63048 | biostudies-arrayexpress
GenomicsIn vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse (ChIP-Seq mouse)
Methylation of cytosines (5meC) is a widespread heritable DNA modification. During mammalian development, two global demethylation events are followed by waves of de novo DNA methylation. In vivo mechanisms of DNA methylation establishment are largely uncharacterized. Here we use Saccharomyces cerev...
ORGANISM(S): Mus musculus 
2015-04-02 | E-GEOD-66910 | biostudies-arrayexpress
UnknownThe aorta in humans and African great apes, and cardiac output and metabolic levels in human evolution.
Not available
S-EPMC10133235 | biostudies-literature
TranscriptomicsMutant p53 Disrupts Mammary Acinar Morphogenesis via the Mevalonate Pathway
p53 is a frequent target for mutation in human tumors and previous studies have revealed that these missense mutant proteins can actively contribute to tumorigenesis. To elucidate how mutant p53 might contribute to mammary carcinogenesis we employed a three-dimensional (3D) culture model. In 3D cul...
ORGANISM(S): Homo sapiens 
2012-02-13 | E-GEOD-31812 | biostudies-arrayexpress
UnknownEZH2 directs HER2+ breast cancer progression through the modulation of epithelial plasticity
Not available
S-SCDT-10_1038-S44319-026-00691-X | biostudies-other
TranscriptomicsMIWI2 and MILI have differential effects on piRNA biogenesis and DNA methylation
In developing male germ cells, prospermatogonia, two Piwi proteins, MILI and MIWI2, use piRNA guides to repress transposable element (TE) expression and ensure genome stability and proper gametogenesis. In addition to their roles in post-transcriptional TE repression, both proteins are required for ...
ORGANISM(S): Mus musculus 
2015-07-11 | E-GEOD-70731 | biostudies-arrayexpress
Unknownp53 Represses the Mevalonate Pathway to Mediate Tumor Suppression.
Not available
S-EPMC6483089 | biostudies-literature
TranscriptomicsIn vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse (RNA-Seq)
Methylation of cytosines (5meC) is a widespread heritable DNA modification. During mammalian development, two global demethylation events are followed by waves of de novo DNA methylation. In vivo mechanisms of DNA methylation establishment are largely uncharacterized. Here we use Saccharomyces cerev...
ORGANISM(S): Saccharomyces cerevisiae 
2015-04-02 | E-GEOD-66908 | biostudies-arrayexpress
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