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MetabolomicsLongitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiologica...

2020-09-08 | MTBLS1396 | MetaboLights
TranscriptomicsNotch1-driven transcriptional changes in a mouse model of T-ALL
T-cell acute lymphoblastic leukemia (T-ALL) is an immature hematopoietic malignancy driven mainly by oncogenic activation of NOTCH1 signaling. In this study we used a mouse model of T-ALL through the overexpression of the intarcellular transcriptionally active part of Notch1 (N1-IC). This model fait...
ORGANISM(S): Mus musculus 
2012-01-10 | E-GEOD-34554 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse lung from individuals with airway hyperactivity and goblet cell metaplasia post-Sendai virus infection
Mice representing phenotypic extremes of airway hyperreactivity and goblet cell metaplasia post-Sendai virus infection were identified from a 500 mouse F2 cohort (CB6F2/J). Whole lung RNA from 3 mice at each extreme was analyzed via microarray for gene expression. Subsequent pairwise comparisons b...
ORGANISM(S): Mus musculus 
2007-07-06 | E-GEOD-3925 | biostudies-arrayexpress
UnknownClinical outcomes of patients with unsuccessful mechanical thrombectomy versus best medical management of medium vessel occlusion stroke in the middle cerebral artery territory.
Not available
S-EPMC12284089 | biostudies-literature
TranscriptomicsGene expression quantitative trait loci (eQTL) study using the HB3Ã?Dd2 genetic cross progeny of P. falciparum
The determinants of transcriptional regulation in malaria parasites remain elusive. The presence of a well-characterized gene expression cascade shared by different Plasmodium falciparum strains could imply that transcriptional regulation and its natural variation do not contribute significantly to ...
ORGANISM(S): Plasmodium falciparum 
2010-05-16 | E-GEOD-12515 | biostudies-arrayexpress
UnknownOutcomes of mechanical thrombectomy in anticoagulated patients with acute distal and medium vessel stroke.
Not available
S-EPMC11569456 | biostudies-literature
UnknownPredictive value of follow-up infarct volume on functional outcomes in middle cerebral artery M2 segment vessel occlusion stroke treated with mechanical thrombectomy.
Not available
S-EPMC11556630 | biostudies-literature
UnknownThe clinical and genetic spectrum of inherited glycosylphosphatidylinositol deficiency disorders.
Not available
S-EPMC11292905 | biostudies-literature
UnknownLiraglutide and Cardiovascular Outcomes in Type 2 Diabetes.
Not available
S-EPMC4985288 | biostudies-literature
UnknownRegulatory variants in TCF7L2 are associated with thoracic aortic aneurysm.
Not available
S-EPMC8456156 | biostudies-literature
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