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TranscriptomicsTranscription profiling of brain hemispheres from R6/2 transgenic mice treated with a combination drug therapy (tacrine, moclobemide and creatine) to study the molecular impact of the drug therapy on Huntingtons disease.
Huntington's disease is a genetic disease caused by a single mutation. It is characterised by progressive movement, emotional and cognitive deficits. R6/2 transgenic mice carrying the Huntington's disease mutation have a progressive neurological phenotype, including deterioration in cognitive functi...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-857 | biostudies-arrayexpress
Proteomics,MultiomicsProtrusion vs Cell-body SILAC proteomics
In mesenchymal-like cell migration, cells need to polarise into a protrusive front and a retracting cell body. To understand this process better, we set out to quantify the distribution of cellular proteins between protrusions and cell-body by proteomics, using MDA-MB-231 cells, a highly invasive br...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-03-10 | MSV000079570 | MassIVE
ProteomicsMuSt multiomics
Multiomics of faecal samples collected from individuals in families with multiple cases of type 1 diabetes mellitus (T1DM) over 3 or 4 months. Metagenomic and metatranscriptomic sequencing and metaproteomics were carried out, as well as whole human genome sequencing. Phenotypic data is available.
ORGANISM(S): Mixed Culture Metagenome (ncbitaxon:1306859) 
2017-10-19 | MSV000081630 | MassIVE
MetabolomicsAn Unbiased Lipid Phenotyping Approach To Study the Genetic Determinants of Lipids and Their Association with Coronary Heart Disease Risk Factors
Direct infusion high-resolution mass spectrometry (DIHRMS) is a novel, high-throughput approach to rapidly and accurately profile hundreds of lipids in human serum without prior chromatography, facilitating in-depth lipid phenotyping for large epidemiological studies to reveal the detailed associati...
2024-02-02 | MTBLS4461 | MetaboLights
TranscriptomicsRNAi knock down of LEDGF transcript from the PSIP1 gene in human 293T cells reveals a role for LEDFG/p75 in targeting HIV integration
The LEDGF transcript from the PSIP1 gene was knocked down using RNAi technology. The resulting 293T derived cell line (293TsiLL) was compared to a control cell line (293TsiScram) using microarray analysis. Genes identified as being modulated by LEDGF were preferential targets of HIV integration. Ex...
ORGANISM(S): Homo sapiens 
2007-10-27 | E-GEOD-3485 | biostudies-arrayexpress
UnknownEarly induction of cytokine release syndrome by rapidly generated CAR T cells in preclinical models
Not available
S-SCDT-10_1038-S44321-024-00055-9 | biostudies-other
ProteomicsStappia 28M-7 - Three new deep-sea bacteria isolated from Atlantic sponges and evidence for the biosynthesis of the antimicrobial thiazole alkaloid agrochelin
OSMAC guided bioprospecting of Atlantic sponges reveals novel bacterial species and evidence for the antimicrobial thiazole alkaloid agrochelin II A tandem mass spec data file from the crude extract of Stappia 28M-7 Taxonomy ID: 2762596
ORGANISM(S): Stappia (ncbitaxon:152161) 
2025-08-11 | MSV000098784 | MassIVE
GenomicsA Genome-Wide Association Study of Lung Cancer Risk

Three genetic loci for lung cancer risk have been identified by genome-wide association studies (GWAS), but inherited susceptibility to specific histologic types of lung cancer is not well established. We conducted a GWAS of lung cancer and its major histologic types genotyping 515,922 single n...

phs000336.v1.p1 | EGA
TranscriptomicsTranscription profiling of human breast cancer MDA-MB-231 cells treated with PTHrP and control siRNA
Parathyroid hormone-related protein (PTHrP) is overexpressed in many cancer types. This secretory protein can induce hypercalcaemia of malignancy by mimicking the action of calcium-regulating parathyroid hormone (PTH). PTHrP may also be involved in the regulation of migration, invasion, proliferatio...
ORGANISM(S): Homo sapiens 
2007-12-12 | E-GEOD-4292 | biostudies-arrayexpress
UnknownAge- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers.
Not available
S-EPMC5019754 | biostudies-literature
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