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TranscriptomicsGlucosylated hydroxymethyluracil (DNA base J) prevents transcriptional read-through in Leishmania
Some T's in nuclear DNA of trypanosomes and Leishmania are hydroxylated and glucosylated to yield base J (?-D-glucosyl-hydroxymethyluracil). In Leishmania about 99% of J is located in telomeric repeats. We show here that most of the remaining J is located at chromosome-internal RNA Polymerase II ter...
ORGANISM(S): Leishmania major 
2011-10-15 | E-GEOD-32976 | biostudies-arrayexpress
UnknownPaul Atkins
Not available
S-EPMC1124996 | biostudies-literature
MetabolomicsIntegration of time-series meta-omics data reveals how microbial ecosystems respond to disturbance
The development of reliable, mixed-culture biotechnological processes hinges on understanding how microbial ecosystems respond to disturbances. Here we reveal extensive phenotypic plasticity and niche complementarity in oleaginous microbial populations from a biological wastewater treatment plant. W...
2021-04-06 | MTBLS2021 | MetaboLights
ProteomicsSpaceflight adaptation requires organ specific alterations in the proteomes of Arabidopsis
This experiment was launched on STS-129 in 2009 and was supported by NASA grant NNX07AH27G - Transgenic Plant Biomonitors of Space Flight Exposure to R.J. Ferl and A-L. Paul.

Life in spaceflight demonstrates remarkable adaptive processes within the specialized environments of space vehicles w...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2015-03-24 | PXD001179 | Pride
Proteomics Space biology Iss Gene expression 
UnknownEstimating the population-level prevalence of antimicrobial-resistant enteric bacteria from latrine samples.
Not available
S-EPMC9392229 | biostudies-literature
UnknownClinical management of chronic mesenteric ischemia.
Not available
S-EPMC6498801 | biostudies-literature
TranscriptomicsThree commercial array platforms compared for DNA copy number detection with DNA isolated from FFPE tissue [NimbleGen]
Formalin-fixed, paraffin-embedded (FFPE) archival tissue is an important source of DNA material. The most commonly used technique to identify copy number aberrations from chromosomal DNA in tumorigenesis is array comparative genomic hybridization (aCGH). Although copy number analysis using DNA from ...
ORGANISM(S): Homo sapiens 
2012-01-17 | E-GEOD-30120 | biostudies-arrayexpress
TranscriptomicsTen percent of aberrant cells is sufficient for detection of DNA copy number alterations (part 1)
Array Comparative Genomic Hybridization (aCGH) is a widely used technique to assess chromosomal copy number alterations. Chromosomal content, however, is often not uniform throughout cell populations. The aim of our present study is to evaluate to what extent aCGH can detect DNA copy number alterat...
ORGANISM(S): Homo sapiens 
2012-10-21 | E-GEOD-36856 | biostudies-arrayexpress
TranscriptomicsTen percent of aberrant cells is sufficient for detection of DNA copy number alterations (part 5)
Array Comparative Genomic Hybridization (aCGH) is a widely used technique to assess chromosomal copy number alterations. Chromosomal content, however, is often not uniform throughout cell populations. The aim of our present study is to evaluate to what extent aCGH can detect DNA copy number alterat...
ORGANISM(S): Homo sapiens 
2012-10-21 | E-GEOD-36992 | biostudies-arrayexpress
TranscriptomicsTen percent of aberrant cells is sufficient for detection of DNA copy number alterations (part 3)
Array Comparative Genomic Hybridization (aCGH) is a widely used technique to assess chromosomal copy number alterations. Chromosomal content, however, is often not uniform throughout cell populations. The aim of our present study is to evaluate to what extent aCGH can detect DNA copy number alterat...
ORGANISM(S): Homo sapiens 
2012-10-21 | E-GEOD-36989 | biostudies-arrayexpress
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