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TranscriptomicsGene expression in male and female smokers
Smoking is the second leading cause of preventable death in the United States. Cohort epidemiological studies have demonstrated that women are more vulnerable to cigarette-smoking induced diseases than their male counterparts, however, the molecular basis of these differences has been remained unkn...
ORGANISM(S): Homo sapiens 
2015-05-01 | E-GEOD-47415 | biostudies-arrayexpress
TranscriptomicsGene expression in blood of mice with internal exposure to Cs-137
Cesium-137 is a radionuclide of concern in fallout from reactor accidents or nuclear detonations. When ingested or inhaled, it can expose the entire body for an extended period of time, potentially contributing to serious health consequences ranging from acute radiation syndrome to increased cancer...
ORGANISM(S): Mus musculus 
2014-08-31 | E-GEOD-52690 | biostudies-arrayexpress
TranscriptomicsRadiation responses in peripheral white blood cells of smokers and non-smokers
Understanding the possible impact of potential confounding factors is necessary for any approach to radiation biodosimetry. Potential confounding factors have not been fully addressed for gene expression-based biodosimetry approaches, such as we are developing. To begin addressing this need, we ha...
ORGANISM(S): Homo sapiens 
2011-03-16 | E-GEOD-23515 | biostudies-arrayexpress
TranscriptomicsGene expression in human peripheral blood 48 hours after exposure to ionizing radiation
Analysis of human peripheral blood 48 hours after irradiation ex vivo with graded doses of gamma rays. Results have been used in building and testing classifiers to predict exposure dose for use in radiological triage, and also provide insight into immune cell responses. Results were compared with...
ORGANISM(S): Homo sapiens 
2013-09-11 | E-GEOD-44201 | biostudies-arrayexpress
TranscriptomicsGene expression in mouse blood following low dose-rate or acute x-ray exposure
Radiation biodosimetry can play a critical role in the response to a large-scale radiologic emergency, and gene expression profiles have shown promise for providing biodosimetric information. This study was designed to test if gene expression could be used to distinguish between doses received from ...
ORGANISM(S): Mus musculus 
2015-05-14 | E-GEOD-62623 | biostudies-arrayexpress
TranscriptomicsPrediction of in vivo radiation dose in radiotherapy patients using ex vivo and in vivo gene expression signatures
After defining a gene expression signature that predicted radiation exposure dose with high accuracy in human peripheral white blood cells irradiated ex vivo, we now demonstrate the predictive power of gene expression signatures in blood from patients undergoing total body irradiation. Using whole ...
ORGANISM(S): Homo sapiens 
2011-01-31 | E-GEOD-20162 | biostudies-arrayexpress
TranscriptomicsIn vivo gene expression changes in human blood cells in response to radiation therapy.
Our in vivo study measures miRNA and gene expression changes in human blood cells in response to ionizing radiation in order to develop miRNA signatures that can be used as biomarkers for radiation exposure. Blood was collected from 8 radiotherapy patients immediately prior to and at 4 h after total...
ORGANISM(S): Homo sapiens 
2010-08-05 | E-GEOD-23393 | biostudies-arrayexpress
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